Glycosylation and Aging (CROSBI ID 70619)
Prilog u knjizi | izvorni znanstveni rad
Podaci o odgovornosti
Cindrić, Ana ; Krištić, Jasminka ; Martinić Kavur, Marina ; Pezer, Marija
engleski
Glycosylation and Aging
Human lifespan has increased significantly in the last 200 years, emphasizing our need to age healthily. Insights into molecular mechanisms of aging might allow us to slow down its rate or even revert it. Similar to aging, glycosylation is regulated by an intricate interplay of genetic and environmental factors. The dynamics of glycopattern variation during aging has been mostly explored for plasma/serum and immunoglobulin G (IgG) N-glycome, as we describe thoroughly in this chapter. In addition, we discuss the potential functional role of agalactosylated IgG glycans in aging, through modulation of inflammation level, as proposed by the concept of inflammaging. We also comment on the potential to use the plasma/serum and IgG N-glycome as a biomarker of healthy aging and on the interventions that modulate the IgG glycopattern. Finally, we discuss the current knowledge about animal models for human plasma/serum and IgG glycosylation and mention other, less explored, instances of glycopattern changes during organismal aging and cellular senescence.
Aging ; Biological age ; Glycosylation ; IgG N-glycome ; Inflammaging ; Plasma N-glycome
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Podaci o prilogu
341-373.
objavljeno
10.1007/978-3-030-70115-4_17
Podaci o knjizi
The Role of Glycosylation in Health and Disease
Lauc, Gordan ; Trbojević-Akmačić Irena
Cham: Springer
2021.
978-3-030-70115-4