engleski

Coordination chemistry of heterocycle and ferrocene conjugates

Ferrocene represents a significant pharmacophore in medicinal chemistry along with its derivatives being important ligands in coordination chemistry. Click chemistry involves a set of widely applicable stereospecific reactions with high yield and without unwanted side reactions. The copper-catalysed azide–alkyne cycloaddition (CuAAC) reaction represents a simple approach to the synthesis and fine-tuning the properties of 1, 2, 3-triazole ligands. Our goal was to prepare novel mono- and bis- ferrocenyl derivatives connected to an aromatic amine through a 1, 2, 3- triazolyl linker. Conjugates of ferrocene and heterocycles were prepared by CuAAC reactions of propargylated aromatic amines and ferrocene azides. Conjugates of ferrocene and heterocycles were used as ligands in the synthesis of Zn(II) and Cu(II) metal complexes and the stoichiometry and stereochemistry of the obtained complexes was examined. The structures of the newly synthesized derivatives were confirmed by 1H and 13C NMR spectroscopy. The spectroscopic properties of the obtained complexes were investigated by NMR, UV- Vis and IR spectroscopy. Crystal structures of several Cu(II) complexes containing mono- and bis- ferrocenyl ligands were determined by single- crystal X-ray diffraction.

1, 2, 3-triazole ; transition metal complex

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