engleski

Development of superparamagnetic magnetite nanocarriers for targeted drug delivery

Magnetic drug targeting is one of the most promising approaches for the treatment of various diseases in which magnetic drug nanocarriers are manipulated by external magnetic fields to reach the target area. [1] In recent decades, magnetite nanoparticles (MNPs) have attracted much attention due to properties such as superparamagnetism, high surface area, and easy separation under external magnetic fields. [2] Therefore, MNPs were synthesized by the solvothermal method. To enhance the surface functionality, the synthesized nanoparticles were stabilized by coating with poly(ethylene glycol) PEG 4000 Da, a hydrophilic and biocompatible polymer. Both bare and PEG4000 coated MNPs were characterized by various techniques to appraise their suitability for drug delivery. The structure and morphology of bare and coated MNPs were characterized using an X-ray powder diffraction (XRPD), field emission scanning electron microscopy (FE-SEM), and atomic force microscopy (AFM). Furthermore, the thermal property and colloidal stability of synthesized MNPs were studied. The magnetic measurements were carried out using a commercial Quantum Design superconducting magnetometer (SQUID). The interactions between iron, PEG, and quercetin were studied by Fourier Transform-Infrared spectroscopy (FTIR). Within this research, quercetin as a model drug was investigated. The problems related to low solubility and instability in the physiological environment of quercetin are currently a challenge for medical application. [3] The UV/VIS spectroscopy was used to study quercetin loading and release from the prepared MNPs. In vitro kinetics of quercetin release has been controlled by using combined stationary and alternating magnetic fields. In addition, the superparamagnetic MNPs exhibited excellent chemical and physical properties, which makes them promising nanocarriers for targeted therapeutic applications.

superparamagnetic nanocarriers ; quercetin ; drug delivery

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