engleski

Synthesis and biological activity of novel n- substituted benzimidazole derived acrylonitriles

The study of heterocyclic chemistry is a vast and expanding area of chemistry because of obvious application of compounds derived from heterocyclic rings in pharmacy, medicine and other fields. Among the various classes of nitrogen‐containing heterocyclic compounds, benzimidazole is an important pharmacophore and a privileged structure in medicinal chemistry. Nowadays, it is a moiety of choice which possesses many pharmacological properties. Due to their special structural features and electron- rich environment, benzimidazole containing drugs bind to a variety of therapeutic targets, thereby exhibiting a broad spectrum of bioactivities.1 In this paper, we report the synthesis of novel biologically active N-substituted benzimidazole derivatives, related to 2, 3-disubstituted acrylonitriles. Novel compounds were prepared by classical reactions of organic chemistry and by microwave assisted reactions. Acrylonitrile derivatives bearing benzimidazole nuclei were prepared by aldol condensation of N-substituted 2- cyanomethylbenzimidazoles with corresponding hydroxy, methoxy, 4-N, N-dimethyl-amino and 4- N, N- diethyl-amino subsituted benzaldehydes in moderate to good yields.2 All newly prepared compounds will be screened for their antioxidant capacity using several spectroscopic methods as well as antiproliferative activity on several human cancer cells in vitro.

acrylonitriles ; benzimidazoles ; computational analysis ; tubulin polymerization

nije evidentirano