Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 114141

AGE Containing Immune Complexes in Diabetic and Nondiabetic Patients with Coronary Artery Disease


Turk, Zdenka; Šesto, Mihajlo; Turk, Nikša; Skodlar, Jasna; Ferenčak, Goran; Stavljenić-Rukavina, Ana
AGE Containing Immune Complexes in Diabetic and Nondiabetic Patients with Coronary Artery Disease // Diabetes, 52 (2003), suppl 1. (podatak o recenziji nije dostupan, kongresno priopcenje, znanstveni)


CROSBI ID: 114141 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
AGE Containing Immune Complexes in Diabetic and Nondiabetic Patients with Coronary Artery Disease

Autori
Turk, Zdenka ; Šesto, Mihajlo ; Turk, Nikša ; Skodlar, Jasna ; Ferenčak, Goran ; Stavljenić-Rukavina, Ana

Izvornik
Diabetes (0012-1797) 52 (2003), Suppl 1;

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kongresno priopcenje, znanstveni

Ključne riječi
Immune complexes; Coronary artery disease

Sažetak
Advanced glycation endproducts (AGE) and anti-AGE antibodies in free and immune complex bound form were assayed in serum of diabetic (n=69) and nondiabetic (n=78) patients with coronary artery disease (CAD), and of control subjects (n=47) free from vascular disease. Blocking ELISA was used to test immunoreactivity against AGE epitope(s), and competitive ELISA to measure total AGE content. Immune complexes containing AGE moiety was detected by ELISA using an immunochemical bridge and soluble AGE-IC were precipitated from serum by polyethylene glycol and analysed. Anti-AGE immunoreactivity was significantly (p<0.05) higher in diabetic than in control subjects. Although great dispersion of anti-AGE antibody titre was observed in nondiabetic CAD patients, the difference did not reach statistical significance from control subjects. Both diabetic and nondiabetic CAD patients had a higher level of circulating immune complexes containing AGE moiety as antigen than control subjects (p<0.01). Study patients showed positive correlation between serum AGE level and AGE-immune complexes (DM+CAD: r=0.3, p<0.01 ; CAD: r=0.26, p<0.01), whereas no such correlation was recorded in controls (r=0.08). In conclusion, this study demonstrate an increased level of soluble AGE-IC in patients with CAD, either with or without diabetes, suggesting that AGE-IC might be involved in the atherosclerotic process, either as the result of it or as part of the pathophysiologic process.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija



POVEZANOST RADA


Projekti:
0045003

Ustanove:
Klinika za dijabetes, endokrinologiju i bolesti metabolizma Vuk Vrhovac

Profili:

Avatar Url Zdenka Turk (autor)

Avatar Url Goran Ferenčak (autor)

Avatar Url Nikša Turk (autor)

Avatar Url Ana Stavljenić (autor)

Avatar Url Mihajlo Šesto (autor)

Avatar Url Jasna Mesarić (autor)


Citiraj ovu publikaciju

Turk, Zdenka; Šesto, Mihajlo; Turk, Nikša; Skodlar, Jasna; Ferenčak, Goran; Stavljenić-Rukavina, Ana
AGE Containing Immune Complexes in Diabetic and Nondiabetic Patients with Coronary Artery Disease // Diabetes, 52 (2003), suppl 1. (podatak o recenziji nije dostupan, kongresno priopcenje, znanstveni)
Turk, Z., Šesto, M., Turk, N., Skodlar, J., Ferenčak, G. & Stavljenić-Rukavina, A. (2003) AGE Containing Immune Complexes in Diabetic and Nondiabetic Patients with Coronary Artery Disease. Diabetes, 52 (suppl 1).
@article{article, year = {2003}, pages = {A169}, keywords = {Immune complexes, Coronary artery disease}, journal = {Diabetes}, volume = {52}, number = {suppl 1}, issn = {0012-1797}, title = {AGE Containing Immune Complexes in Diabetic and Nondiabetic Patients with Coronary Artery Disease}, keyword = {Immune complexes, Coronary artery disease} }
@article{article, year = {2003}, pages = {A169}, keywords = {Immune complexes, Coronary artery disease}, journal = {Diabetes}, volume = {52}, number = {suppl 1}, issn = {0012-1797}, title = {AGE Containing Immune Complexes in Diabetic and Nondiabetic Patients with Coronary Artery Disease}, keyword = {Immune complexes, Coronary artery disease} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





Contrast
Increase Font
Decrease Font
Dyslexic Font