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Pregled bibliografske jedinice broj: 1141162

Photodynamic Inactivation of Legionella pneumophila Biofilm Formation by Cationic Tetra- and Tripyridylporphyrins in Waters of Different Hardness


Mušković, Martina; Ćavar, Iva; Lesar, Andrija; Lončarić, Martin; Malatesti, Nela; Gobin, Ivana
Photodynamic Inactivation of Legionella pneumophila Biofilm Formation by Cationic Tetra- and Tripyridylporphyrins in Waters of Different Hardness // International Journal of Molecular Sciences, 22 (2021), 16; 9095, 19 doi:10.3390/ijms22169095 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1141162 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Photodynamic Inactivation of Legionella pneumophila Biofilm Formation by Cationic Tetra- and Tripyridylporphyrins in Waters of Different Hardness

Autori
Mušković, Martina ; Ćavar, Iva ; Lesar, Andrija ; Lončarić, Martin ; Malatesti, Nela ; Gobin, Ivana

Izvornik
International Journal of Molecular Sciences (1661-6596) 22 (2021), 16; 9095, 19

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Porphyrins ; Disinfection ; Legionella pneumophila ; Biofilm ; Water hardness ; Singlet oxygen

Sažetak
The bacterium Legionella pneumophila is still one of the probable causes of waterborne diseases, causing serious respiratory illnesses. In the aquatic systems, L. pneumophila exists inside free-living amoebae or can form biofilms. Currently developed disinfection methods are not sufficient for complete eradication of L. pneumophila biofilms in water systems of interest. Photodynamic inactivation (PDI) is a method that results in an antimicrobial effect by using a combination of light and a photosensitizer (PS). In this work, the effect of PDI in waters of natural origin and of different hardness, as a treatment against L. pneumophila biofilm, was investigated. Three cationic tripyridylporphyrins, which were previously described as efficient agents against L. pneumophila alone, were used as PSs. We studied how differences in water hardness affect the PSs’ stability, the production of singlet oxygen, and the PDI activity on L. pneumophila adhesion and biofilm formation and in biofilm destruction. Amphiphilic porphyrin showed a stronger tendency for aggregation in hard and soft water, but its production of singlet oxygen was higher in comparison to tri- and tetracationic hydrophilic porphyrins that were stable in all water samples. All three studied porphyrins were shown to be effective as PDI agents against the adhesion of the L. pneumophila to polystyrene, against biofilm formation, and in the destruction of the formed biofilm, in their micromolar concentrations. However, a higher number of dissolved ions, i.e., water hardness, generally reduced somewhat the PDI activity of all the porphyrins at all tested biofilm growth stages.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)



POVEZANOST RADA


Projekti:
NadSve-Sveučilište u Rijeci-uniri-prirod-18-173 - Priprema lipidnih konjugata piridilporfirina, njihova karakterizacija i fotodinamička aktivnost (Malatesti, Nela, NadSve - UNIRI PROJEKTI) ( POIROT)
NadSve-Sveučilište u Rijeci-uniri-biomed-18-171 - Oportunistički patogeni vodoopskrbnog sustava: novi izazov u obradi voda (Gobin, Ivana, NadSve ) ( POIROT)
EK-EFRR-KK.01.1.1.01.0001 - Potpora vrhunskim istraživanjima Centra izvrsnosti za napredne materijale i senzore (Ivanda, Mile; Jakšić, Milko; Stipčević, Mario; Kralj, Marko, EK - KK.01.1.1.01) ( POIROT)

Ustanove:
Medicinski fakultet, Rijeka,
Institut "Ruđer Bošković", Zagreb,
Sveučilište u Rijeci - Odjel za biotehnologiju

Citiraj ovu publikaciju

Mušković, Martina; Ćavar, Iva; Lesar, Andrija; Lončarić, Martin; Malatesti, Nela; Gobin, Ivana
Photodynamic Inactivation of Legionella pneumophila Biofilm Formation by Cationic Tetra- and Tripyridylporphyrins in Waters of Different Hardness // International Journal of Molecular Sciences, 22 (2021), 16; 9095, 19 doi:10.3390/ijms22169095 (međunarodna recenzija, članak, znanstveni)
Mušković, M., Ćavar, I., Lesar, A., Lončarić, M., Malatesti, N. & Gobin, I. (2021) Photodynamic Inactivation of Legionella pneumophila Biofilm Formation by Cationic Tetra- and Tripyridylporphyrins in Waters of Different Hardness. International Journal of Molecular Sciences, 22 (16), 9095, 19 doi:10.3390/ijms22169095.
@article{article, year = {2021}, pages = {19}, DOI = {10.3390/ijms22169095}, chapter = {9095}, keywords = {Porphyrins, Disinfection, Legionella pneumophila, Biofilm, Water hardness, Singlet oxygen}, journal = {International Journal of Molecular Sciences}, doi = {10.3390/ijms22169095}, volume = {22}, number = {16}, issn = {1661-6596}, title = {Photodynamic Inactivation of Legionella pneumophila Biofilm Formation by Cationic Tetra- and Tripyridylporphyrins in Waters of Different Hardness}, keyword = {Porphyrins, Disinfection, Legionella pneumophila, Biofilm, Water hardness, Singlet oxygen}, chapternumber = {9095} }
@article{article, year = {2021}, pages = {19}, DOI = {10.3390/ijms22169095}, chapter = {9095}, keywords = {Porphyrins, Disinfection, Legionella pneumophila, Biofilm, Water hardness, Singlet oxygen}, journal = {International Journal of Molecular Sciences}, doi = {10.3390/ijms22169095}, volume = {22}, number = {16}, issn = {1661-6596}, title = {Photodynamic Inactivation of Legionella pneumophila Biofilm Formation by Cationic Tetra- and Tripyridylporphyrins in Waters of Different Hardness}, keyword = {Porphyrins, Disinfection, Legionella pneumophila, Biofilm, Water hardness, Singlet oxygen}, chapternumber = {9095} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • EMBASE (Excerpta Medica)
  • PubMed


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