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Pregled bibliografske jedinice broj: 1140282

Mechanochemical Prebiotic Peptide Bond Formation


Stolar, Tomislav; Grubešić, Saša; Cindro, Nikola; Meštrović, Ernest; Užarević, Krunoslav; Hernández, José G.
Mechanochemical Prebiotic Peptide Bond Formation // Angewandte Chemie. International edition, 60 (2021), 23; 12727-12731 doi:10.1002/anie.202100806 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1140282 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Mechanochemical Prebiotic Peptide Bond Formation

Autori
Stolar, Tomislav ; Grubešić, Saša ; Cindro, Nikola ; Meštrović, Ernest ; Užarević, Krunoslav ; Hernández, José G.

Izvornik
Angewandte Chemie. International edition (1433-7851) 60 (2021), 23; 12727-12731

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Amino Acids ; Peptides ; Prebiotic Chemistry ; Mechanochemistry ; Origin of Life

Sažetak
The presence of amino acids on the prebiotic Earth, either stemming from endogenous chemical routes or delivered by meteorites, is consensually accepted. Prebiotically plausible pathways to peptides from inactivated amino acids are still unclear as most oligomerization approaches rely on thermodynamically disfavored reactions in solution. Now, a combination of prebiotically plausible minerals and mechanochemical activation enables the oligomerization of glycine at ambient temperature in the absence of water. Raising the reaction temperature increases the degree of oligomerization concomitantly with the formation of a commonly unwanted cyclic glycine dimer (DKP). However, DKP is a productive intermediate in the mechanochemical oligomerization of glycine. The findings of this research show that mechanochemical peptide bond formation is a dynamic process that provides alternative routes towards oligopeptides and establishes new synthetic approaches for prebiotic chemistry.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekti:
HRZZ-IP-2020-02-4702 - Važnost mehanokemijske reaktivnosti u prebiotičkoj kemijskoj evoluciji i njezin prijenos na održivu kemijsku proizvodnju s niskim emisijama (PREBIOMECHEM) (Užarević, Krunoslav, HRZZ - 2020-02) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb,
Prirodoslovno-matematički fakultet, Zagreb

Citiraj ovu publikaciju:

Stolar, Tomislav; Grubešić, Saša; Cindro, Nikola; Meštrović, Ernest; Užarević, Krunoslav; Hernández, José G.
Mechanochemical Prebiotic Peptide Bond Formation // Angewandte Chemie. International edition, 60 (2021), 23; 12727-12731 doi:10.1002/anie.202100806 (međunarodna recenzija, članak, znanstveni)
Stolar, T., Grubešić, S., Cindro, N., Meštrović, E., Užarević, K. & Hernández, J. (2021) Mechanochemical Prebiotic Peptide Bond Formation. Angewandte Chemie. International edition, 60 (23), 12727-12731 doi:10.1002/anie.202100806.
@article{article, author = {Stolar, Tomislav and Grube\v{s}i\'{c}, Sa\v{s}a and Cindro, Nikola and Me\v{s}trovi\'{c}, Ernest and U\v{z}arevi\'{c}, Krunoslav and Hern\'{a}ndez, Jos\'{e} G.}, year = {2021}, pages = {12727-12731}, DOI = {10.1002/anie.202100806}, keywords = {Amino Acids, Peptides, Prebiotic Chemistry, Mechanochemistry, Origin of Life}, journal = {Angewandte Chemie. International edition}, doi = {10.1002/anie.202100806}, volume = {60}, number = {23}, issn = {1433-7851}, title = {Mechanochemical Prebiotic Peptide Bond Formation}, keyword = {Amino Acids, Peptides, Prebiotic Chemistry, Mechanochemistry, Origin of Life} }
@article{article, author = {Stolar, Tomislav and Grube\v{s}i\'{c}, Sa\v{s}a and Cindro, Nikola and Me\v{s}trovi\'{c}, Ernest and U\v{z}arevi\'{c}, Krunoslav and Hern\'{a}ndez, Jos\'{e} G.}, year = {2021}, pages = {12727-12731}, DOI = {10.1002/anie.202100806}, keywords = {Amino Acids, Peptides, Prebiotic Chemistry, Mechanochemistry, Origin of Life}, journal = {Angewandte Chemie. International edition}, doi = {10.1002/anie.202100806}, volume = {60}, number = {23}, issn = {1433-7851}, title = {Mechanochemical Prebiotic Peptide Bond Formation}, keyword = {Amino Acids, Peptides, Prebiotic Chemistry, Mechanochemistry, Origin of Life} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE
  • Nature Index


Citati:





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