Proteomics: A Tool to Study Platelet Function (CROSBI ID 297579)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Shevchuk, Olga ; Begonja, Antonija Jurak Begonja ; Gambaryan, Stepan ; Totzeck, Matthias ; Rassaf, Tienush ; Huber, Tobias B. ; Greinacher, Andreas ; Renne, Thomas ; Sickmann, Albert
engleski
Proteomics: A Tool to Study Platelet Function
Platelets are components of the blood that are highly reactive, and they quickly respond to multiple physiological and pathophysiological processes. In the last decade, it became clear that platelets are the key components of circulation, linking hemostasis, innate, and acquired immunity. Protein composition, localization, and activity are crucial for platelet function and regulation. The current state of mass spectrometry-based proteomics has tremendous potential to identify and quantify thousands of proteins from a minimal amount of material, unravel multiple post-translational modifications, and monitor platelet activity during drug treatments. This review focuses on the role of proteomics in understanding the molecular basics of the classical and newly emerging functions of platelets. including the recently described role of platelets in immunology and the development of COVID-19.The state-of-the-art proteomic technologies and their application in studying platelet biogenesis, signaling, and storage are described, and the potential of newly appeared trapped ion mobility spectrometry (TIMS) is highlighted. Additionally, implementing proteomic methods in platelet transfusion medicine, and as a diagnostic and prognostic tool, is discussed.
LC-MS/MS ; PTMs ; mass spectrometry ; phosphoproteomics ; platelet transfusion proteomics ; platelets ; precision medicine ; signaling ; targeted proteomics
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Podaci o izdanju
22 (9)
2021.
4776
25
objavljeno
1422-0067
10.3390/ijms22094776
Povezanost rada
Biologija, Temeljne medicinske znanosti