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Pregled bibliografske jedinice broj: 1139981

Proteomics: A Tool to Study Platelet Function


Shevchuk, Olga; Begonja, Antonija Jurak Begonja; Gambaryan, Stepan; Totzeck, Matthias; Rassaf, Tienush; Huber, Tobias B.; Greinacher, Andreas; Renne, Thomas; Sickmann, Albert
Proteomics: A Tool to Study Platelet Function // International journal of molecular sciences, 22 (2021), 9; 4776, 25 doi:10.3390/ijms22094776 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1139981 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Proteomics: A Tool to Study Platelet Function

Autori
Shevchuk, Olga ; Begonja, Antonija Jurak Begonja ; Gambaryan, Stepan ; Totzeck, Matthias ; Rassaf, Tienush ; Huber, Tobias B. ; Greinacher, Andreas ; Renne, Thomas ; Sickmann, Albert

Izvornik
International journal of molecular sciences (1422-0067) 22 (2021), 9; 4776, 25

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
LC-MS/MS ; PTMs ; mass spectrometry ; phosphoproteomics ; platelet transfusion proteomics ; platelets ; precision medicine ; signaling ; targeted proteomics

Sažetak
Platelets are components of the blood that are highly reactive, and they quickly respond to multiple physiological and pathophysiological processes. In the last decade, it became clear that platelets are the key components of circulation, linking hemostasis, innate, and acquired immunity. Protein composition, localization, and activity are crucial for platelet function and regulation. The current state of mass spectrometry-based proteomics has tremendous potential to identify and quantify thousands of proteins from a minimal amount of material, unravel multiple post-translational modifications, and monitor platelet activity during drug treatments. This review focuses on the role of proteomics in understanding the molecular basics of the classical and newly emerging functions of platelets. including the recently described role of platelets in immunology and the development of COVID-19.The state-of-the-art proteomic technologies and their application in studying platelet biogenesis, signaling, and storage are described, and the potential of newly appeared trapped ion mobility spectrometry (TIMS) is highlighted. Additionally, implementing proteomic methods in platelet transfusion medicine, and as a diagnostic and prognostic tool, is discussed.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
Ostalo-ASH-2019 - Nucleolar control of megakaryopoiesis (NucMeg) (Jurak Begonja, Antonija, Ostalo - American Society of Hematology (ASH) Global Research Award) ( POIROT)

Ustanove:
Sveučilište u Rijeci - Odjel za biotehnologiju

Profili:

Avatar Url Antonija Jurak Begonja (autor)

Poveznice na cjeloviti tekst rada:

doi www.mdpi.com

Citiraj ovu publikaciju:

Shevchuk, Olga; Begonja, Antonija Jurak Begonja; Gambaryan, Stepan; Totzeck, Matthias; Rassaf, Tienush; Huber, Tobias B.; Greinacher, Andreas; Renne, Thomas; Sickmann, Albert
Proteomics: A Tool to Study Platelet Function // International journal of molecular sciences, 22 (2021), 9; 4776, 25 doi:10.3390/ijms22094776 (međunarodna recenzija, članak, znanstveni)
Shevchuk, O., Begonja, A., Gambaryan, S., Totzeck, M., Rassaf, T., Huber, T., Greinacher, A., Renne, T. & Sickmann, A. (2021) Proteomics: A Tool to Study Platelet Function. International journal of molecular sciences, 22 (9), 4776, 25 doi:10.3390/ijms22094776.
@article{article, author = {Shevchuk, Olga and Begonja, Antonija Jurak Begonja and Gambaryan, Stepan and Totzeck, Matthias and Rassaf, Tienush and Huber, Tobias B. and Greinacher, Andreas and Renne, Thomas and Sickmann, Albert}, year = {2021}, pages = {25}, DOI = {10.3390/ijms22094776}, chapter = {4776}, keywords = {LC-MS/MS, PTMs, mass spectrometry, phosphoproteomics, platelet transfusion proteomics, platelets, precision medicine, signaling, targeted proteomics}, journal = {International journal of molecular sciences}, doi = {10.3390/ijms22094776}, volume = {22}, number = {9}, issn = {1422-0067}, title = {Proteomics: A Tool to Study Platelet Function}, keyword = {LC-MS/MS, PTMs, mass spectrometry, phosphoproteomics, platelet transfusion proteomics, platelets, precision medicine, signaling, targeted proteomics}, chapternumber = {4776} }
@article{article, author = {Shevchuk, Olga and Begonja, Antonija Jurak Begonja and Gambaryan, Stepan and Totzeck, Matthias and Rassaf, Tienush and Huber, Tobias B. and Greinacher, Andreas and Renne, Thomas and Sickmann, Albert}, year = {2021}, pages = {25}, DOI = {10.3390/ijms22094776}, chapter = {4776}, keywords = {LC-MS/MS, PTMs, mass spectrometry, phosphoproteomics, platelet transfusion proteomics, platelets, precision medicine, signaling, targeted proteomics}, journal = {International journal of molecular sciences}, doi = {10.3390/ijms22094776}, volume = {22}, number = {9}, issn = {1422-0067}, title = {Proteomics: A Tool to Study Platelet Function}, keyword = {LC-MS/MS, PTMs, mass spectrometry, phosphoproteomics, platelet transfusion proteomics, platelets, precision medicine, signaling, targeted proteomics}, chapternumber = {4776} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati:





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