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Pregled bibliografske jedinice broj: 1139297

Real-World Efficacy and Safety of Bevacizumab in the First-Line Treatment of Metastatic Cervical Cancer: A Cohort Study in the Total Population of Croatian Patients


Čerina, Dora; Matković, Višnja; Katić, Kristina; Belac Lovasić, Ingrid; Šeparović, Robert; Canjko, Ivana; Jakšić, Blanka; Petrić Miše, Branka; Bajić, Žarko; Boban, Marijo et al.
Real-World Efficacy and Safety of Bevacizumab in the First-Line Treatment of Metastatic Cervical Cancer: A Cohort Study in the Total Population of Croatian Patients // Journal of oncology, 2021 (2021), 2815623, 8 doi:10.1155/2021/2815623 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1139297 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Real-World Efficacy and Safety of Bevacizumab in the First-Line Treatment of Metastatic Cervical Cancer: A Cohort Study in the Total Population of Croatian Patients

Autori
Čerina, Dora ; Matković, Višnja ; Katić, Kristina ; Belac Lovasić, Ingrid ; Šeparović, Robert ; Canjko, Ivana ; Jakšić, Blanka ; Petrić Miše, Branka ; Bajić, Žarko ; Boban, Marijo ; Vrdoljak Eduard ;

Izvornik
Journal of oncology (1687-8450) 2021 (2021); 2815623, 8

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
cervical cancer ; metastatic carcinoma, bevacizumab
(cervical cancer, metastatic carcinoma, bevacizumab)

Sažetak
Although today it is almost preventable, cervical cancer still represents a significant cancer burden, especially in some developing parts of the world. Since the introduction of bevacizumab in the first- line treatment of metastatic disease, im- provements of the outcomes were noted. However, results from randomized controlled trials are often hard to recreate in the real- world setting. Objective. To assess the real-world efficacy and safety of bevacizumab as a first-line treatment of advanced cervical cancer. Methods. We conducted a retrospective cohort study on the total population of Croatian patients diagnosed with metastatic cervical cancer from 2016 to 2019 who were treated with bevacizumab in combination with cisplatin and paclitaxel (TCB) in the first line. The comparison group was the consecutive sample of patients treated with chemotherapy alone. The primary endpoint was overall survival (OS). Secondary endpoints were progression-free survival (PFS), objective response rate, incidence of adverse events, and the proportion of treatment discontinuation. Results. We enrolled 67 patients treated with TCB and a control group of 62 patients treated with chemotherapy alone. The TCB cohort had significantly longer unadjusted OS with a median of 27.0 (95% CI 18.5 ; not calculable) months, compared to 15.5 (10.7 ; 30.1) months in the chemotherapy-alone cohort. Adjusted OS was not significantly different. PFS was significantly longer for the TCB cohort, with a median of 10.6 (95% CI 8.5 ; 15.4) months, than for the chemotherapy-alone cohort, with a median of 5.4 (95% CI 3.9 ; 9.1) months, even after adjustment for baseline covariates (HRadjusted � 0.60 ; 95% CI 0.39 ; 0.94 ; p � 0.027 ; false discovery rate <5%). Conclusions. In a real-world setting, TCB as a first-line treatment of metastatic cervical cancer was associated with longer PFS, better objective disease control rate, and acceptable toxicity profile in comparison to chemotherapy alone. These results may indicate its utility and potential applicability in other parts of the developing world.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Ustanove:
Klinički bolnički centar Osijek,
KBC "Sestre Milosrdnice",
KBC Split,
Klinički bolnički centar Zagreb,
Klinički bolnički centar Rijeka,
Psihijatrijska bolnica "Sveti Ivan" Zagreb

Poveznice na cjeloviti tekst rada:

doi doi.org

Citiraj ovu publikaciju:

Čerina, Dora; Matković, Višnja; Katić, Kristina; Belac Lovasić, Ingrid; Šeparović, Robert; Canjko, Ivana; Jakšić, Blanka; Petrić Miše, Branka; Bajić, Žarko; Boban, Marijo et al.
Real-World Efficacy and Safety of Bevacizumab in the First-Line Treatment of Metastatic Cervical Cancer: A Cohort Study in the Total Population of Croatian Patients // Journal of oncology, 2021 (2021), 2815623, 8 doi:10.1155/2021/2815623 (međunarodna recenzija, članak, znanstveni)
Čerina, D., Matković, V., Katić, K., Belac Lovasić, I., Šeparović, R., Canjko, I., Jakšić, B., Petrić Miše, B., Bajić, Ž. & Boban, M. (2021) Real-World Efficacy and Safety of Bevacizumab in the First-Line Treatment of Metastatic Cervical Cancer: A Cohort Study in the Total Population of Croatian Patients. Journal of oncology, 2021, 2815623, 8 doi:10.1155/2021/2815623.
@article{article, author = {\v{C}erina, Dora and Matkovi\'{c}, Vi\v{s}nja and Kati\'{c}, Kristina and Belac Lovasi\'{c}, Ingrid and \v{S}eparovi\'{c}, Robert and Canjko, Ivana and Jak\v{s}i\'{c}, Blanka and Petri\'{c} Mi\v{s}e, Branka and Baji\'{c}, \v{Z}arko and Boban, Marijo}, year = {2021}, pages = {8}, DOI = {10.1155/2021/2815623}, chapter = {2815623}, keywords = {cervical cancer, metastatic carcinoma, bevacizumab}, journal = {Journal of oncology}, doi = {10.1155/2021/2815623}, volume = {2021}, issn = {1687-8450}, title = {Real-World Efficacy and Safety of Bevacizumab in the First-Line Treatment of Metastatic Cervical Cancer: A Cohort Study in the Total Population of Croatian Patients}, keyword = {cervical cancer, metastatic carcinoma, bevacizumab}, chapternumber = {2815623} }
@article{article, author = {\v{C}erina, Dora and Matkovi\'{c}, Vi\v{s}nja and Kati\'{c}, Kristina and Belac Lovasi\'{c}, Ingrid and \v{S}eparovi\'{c}, Robert and Canjko, Ivana and Jak\v{s}i\'{c}, Blanka and Petri\'{c} Mi\v{s}e, Branka and Baji\'{c}, \v{Z}arko and Boban, Marijo}, year = {2021}, pages = {8}, DOI = {10.1155/2021/2815623}, chapter = {2815623}, keywords = {cervical cancer, metastatic carcinoma, bevacizumab}, journal = {Journal of oncology}, doi = {10.1155/2021/2815623}, volume = {2021}, issn = {1687-8450}, title = {Real-World Efficacy and Safety of Bevacizumab in the First-Line Treatment of Metastatic Cervical Cancer: A Cohort Study in the Total Population of Croatian Patients}, keyword = {cervical cancer, metastatic carcinoma, bevacizumab}, chapternumber = {2815623} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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