Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 1139220

Presepsin values as markers of severity of sepsis


Aliu-Bejta, Ajete; Atelj, Anita; Kurshumliu, Mentor; Dreshaj, Shemsedin; Baršić, Bruno
Presepsin values as markers of severity of sepsis // International Journal of Infectious Diseases, 95 (2020), 1-7 doi:10.1016/j.ijid.2020.03.057 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1139220 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Presepsin values as markers of severity of sepsis

Autori
Aliu-Bejta, Ajete ; Atelj, Anita ; Kurshumliu, Mentor ; Dreshaj, Shemsedin ; Baršić, Bruno

Izvornik
International Journal of Infectious Diseases (1201-9712) 95 (2020); 1-7

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
C-reactive protein ; SOFA score ; presepsin ; procalcitonin ; sepsis severity

Sažetak
Objectives: Biomarkers are widely used for rapid diagnosis of sepsis. This study evaluated the diagnostic accuracy of presepsin, procalcitonin (PCT), and C-reactive protein (CRP) in differentiating sepsis severity as well as their association with Sepsis-related Organ Failure Assessment (SOFA) score. Methods: One hundred septic patients from two university clinical centers were enrolled in the study during two time periods. New Sepsis-3 definitions were used for sepsis stratification. Biomarkers and SOFA score were evaluated four times during the illness. A sandwich ELISA kit was used for presepsin measurement. Generalized linear mixed effects model was used to test the changes in biomarkers concentrations and SOFA score values during the illness and to estimate the differences between severity groups. Multivariate analysis was used to test the association of biomarkers with SOFA score. Results: Presepsin concentrations were significantly higher on admission in patients with septic shock (n = 34) compared to patients with sepsis (n = 66), mean ± SD: 128.5 ± 47.6 ng/mL vs. 88.6 ± 65.6 ng/mL, respectively (p < 0.001). The same was not observed for PCT and CRP ; their concentrations did not differ significantly between severity groups. A strong correlation of presepsin with SOFA score was also found (p < 0.0001). Conclusions: Presepsin had a good diagnostic ability to differentiate septic shock from sepsis in the study groups. PCT and CRP failed in differentiating sepsis severity.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove:
Klinika za infektivne bolesti "Dr Fran Mihaljević",
Klinička bolnica "Dubrava"

Profili:

Avatar Url Anita Atelj (autor)

Avatar Url Bruno Baršić (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com

Citiraj ovu publikaciju:

Aliu-Bejta, Ajete; Atelj, Anita; Kurshumliu, Mentor; Dreshaj, Shemsedin; Baršić, Bruno
Presepsin values as markers of severity of sepsis // International Journal of Infectious Diseases, 95 (2020), 1-7 doi:10.1016/j.ijid.2020.03.057 (međunarodna recenzija, članak, znanstveni)
Aliu-Bejta, A., Atelj, A., Kurshumliu, M., Dreshaj, S. & Baršić, B. (2020) Presepsin values as markers of severity of sepsis. International Journal of Infectious Diseases, 95, 1-7 doi:10.1016/j.ijid.2020.03.057.
@article{article, author = {Aliu-Bejta, Ajete and Atelj, Anita and Kurshumliu, Mentor and Dreshaj, Shemsedin and Bar\v{s}i\'{c}, Bruno}, year = {2020}, pages = {1-7}, DOI = {10.1016/j.ijid.2020.03.057}, keywords = {C-reactive protein, SOFA score, presepsin, procalcitonin, sepsis severity}, journal = {International Journal of Infectious Diseases}, doi = {10.1016/j.ijid.2020.03.057}, volume = {95}, issn = {1201-9712}, title = {Presepsin values as markers of severity of sepsis}, keyword = {C-reactive protein, SOFA score, presepsin, procalcitonin, sepsis severity} }
@article{article, author = {Aliu-Bejta, Ajete and Atelj, Anita and Kurshumliu, Mentor and Dreshaj, Shemsedin and Bar\v{s}i\'{c}, Bruno}, year = {2020}, pages = {1-7}, DOI = {10.1016/j.ijid.2020.03.057}, keywords = {C-reactive protein, SOFA score, presepsin, procalcitonin, sepsis severity}, journal = {International Journal of Infectious Diseases}, doi = {10.1016/j.ijid.2020.03.057}, volume = {95}, issn = {1201-9712}, title = {Presepsin values as markers of severity of sepsis}, keyword = {C-reactive protein, SOFA score, presepsin, procalcitonin, sepsis severity} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati:





    Contrast
    Increase Font
    Decrease Font
    Dyslexic Font