Bithiophene-Cored, mono-, bis-, and tris-(Trimethylammonium)- Substituted, bis-Triarylborane Chromophores: Effect of the Number and Position of Charges on Cell Imaging and DNA/RNA Sensing (CROSBI ID 297312)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Berger, Sarina M. ; Rühe, Jessica ; Schwarzmann, Johannes ; Phillipps, Alexandra ; Richard, Ann-Katrin ; Ferger, Matthias ; Krummenacher, Ivo ; Tumir, Lidija-Marija ; Ban, Željka ; Crnolatac, Ivo ; Majhen, Dragomira ; Barišić, Ivan ; Piantanida, Ivo ; Schleier, Domenik ; Griesbeck, Stefanie ; Friedrich, Alexandra ; Braunschweig, Holger ; Marder, Todd B.
engleski
Bithiophene-Cored, mono-, bis-, and tris-(Trimethylammonium)- Substituted, bis-Triarylborane Chromophores: Effect of the Number and Position of Charges on Cell Imaging and DNA/RNA Sensing
The synthesis, photophysical, and electrochemical properties of selectively mono-, bis- and tris-dimethylamino- and trimethylammonium-substituted bis-triarylborane bithiophene chromophores are presented along with the water solubility and singlet oxygen sensitizing efficiency of the cationic compounds Cat1+, Cat2+, Cat(i)2+, and Cat3+. Comparison with the mono- triarylboranes reveals the large influence of the bridging unit on the properties of the bistriarylboranes, especially those of the cationic compounds. Based on these preliminary investigations, the interactions of Cat1+, Cat2+, Cat(i)2+, and Cat3+ with DNA, RNA, and DNApore were investigated in buffered solutions. The same compounds were investigated for their ability to enter and localize within organelles of human lung carcinoma (A549) and normal lung (WI38) cells showing that not only the number of charges but also their distribution over the chromophore influences interactions and staining properties.
boron ; bioimaging ; luminescence ; singlet oxygen ; nucleic acid
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Podaci o izdanju
27
2021.
14057-14072
objavljeno
0947-6539
1521-3765
10.1002/chem.202102308
Povezanost rada
Kemija