Reprogramming of tyrosine phosphorylation regulated signalling pathways by HPV oncoproteins (CROSBI ID 705569)
Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Szalmás, Anita ; Tomaić, Vjekoslav ; Massimi, Paola ; Gyöngyösi, Eszter ; Kónya, József ; Banks, Lawrence
engleski
Reprogramming of tyrosine phosphorylation regulated signalling pathways by HPV oncoproteins
Activation of signaling pathways ensuring cell growth are essential for the proliferative competence of human papillomavirus (HPV) infected cells. Kinases and phosphatases are the key regulators of cellular growth control pathways. Recently identified cellular targets of HPV E7 are certain cytoplasmic protein tyrosine kinases and phosphatases, such as Src, PTPN14, and PTPN21, which have been linked to the control of multiple cellular growth pathways. We showed that the E7 proteins of both high-risk and low-risk mucosal HPV types can interact with certain non-receptor kinases and phosphatases. These interactions can happen independently of pRb regulation. We also showed that E7 can influence the stability of these regulatory proteins, for example by inducing proteasome mediated degradation of certain cytoplasmic phosphatases.
HPV E7 ; PTPN14 ; PTPN21
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Podaci o prilogu
171-172.
2017.
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objavljeno
Podaci o matičnoj publikaciji
Acta microbiologica et immunologica Hungarica
Akadémiai Kiadó
1217-8950
1588-2640
Podaci o skupu
5th Central European Forum for Microbiology
pozvano predavanje
18.10.2017-20.10.2017
Keszthely, Mađarska
Povezanost rada
Biologija, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)