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izvor podataka: crosbi

Reprogramming of tyrosine phosphorylation regulated signalling pathways by HPV oncoproteins (CROSBI ID 705569)

Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija

Szalmás, Anita ; Tomaić, Vjekoslav ; Massimi, Paola ; Gyöngyösi, Eszter ; Kónya, József ; Banks, Lawrence Reprogramming of tyrosine phosphorylation regulated signalling pathways by HPV oncoproteins // Acta microbiologica et immunologica Hungarica. 2017. str. 171-172

Podaci o odgovornosti

Szalmás, Anita ; Tomaić, Vjekoslav ; Massimi, Paola ; Gyöngyösi, Eszter ; Kónya, József ; Banks, Lawrence

engleski

Reprogramming of tyrosine phosphorylation regulated signalling pathways by HPV oncoproteins

Activation of signaling pathways ensuring cell growth are essential for the proliferative competence of human papillomavirus (HPV) infected cells. Kinases and phosphatases are the key regulators of cellular growth control pathways. Recently identified cellular targets of HPV E7 are certain cytoplasmic protein tyrosine kinases and phosphatases, such as Src, PTPN14, and PTPN21, which have been linked to the control of multiple cellular growth pathways. We showed that the E7 proteins of both high-risk and low-risk mucosal HPV types can interact with certain non-receptor kinases and phosphatases. These interactions can happen independently of pRb regulation. We also showed that E7 can influence the stability of these regulatory proteins, for example by inducing proteasome mediated degradation of certain cytoplasmic phosphatases.

HPV E7 ; PTPN14 ; PTPN21

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Podaci o prilogu

171-172.

2017.

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objavljeno

Podaci o matičnoj publikaciji

Acta microbiologica et immunologica Hungarica

Akadémiai Kiadó

1217-8950

1588-2640

Podaci o skupu

5th Central European Forum for Microbiology

pozvano predavanje

18.10.2017-20.10.2017

Keszthely, Mađarska

Povezanost rada

Biologija, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

Indeksiranost