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Pregled bibliografske jedinice broj: 1138356

Human papillomaviruses: From Infectious Entry to Malignancy


Tomaić, Vjekoslav
Human papillomaviruses: From Infectious Entry to Malignancy // 5. Hrvatski simpozij o prevenciji i liječenju početnog raka vrata maternice s međunarodnim sudjelovanjem
Zagreb, Hrvatska, 2019. str. 2-2 (pozvano predavanje, recenziran, sažetak, znanstveni)


CROSBI ID: 1138356 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Human papillomaviruses: From Infectious Entry to Malignancy

Autori
Tomaić, Vjekoslav

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
5. Hrvatski simpozij o prevenciji i liječenju početnog raka vrata maternice s međunarodnim sudjelovanjem / - , 2019, 2-2

Skup
5. Hrvatski simpozij o prevenciji i liječenju početnog raka vrata maternice s međunarodnim sudjelovanjem

Mjesto i datum
Zagreb, Hrvatska, 26.01.2019

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Recenziran

Ključne riječi
HPV ; cancer ; E6 and E7 oncoproteins

Sažetak
Human Papillomaviruses (HPVs) are major causative agents of human malignancies with cervical cancer being the most important. The virus infects differentiating epithelia where its life cycle is strictly dependent upon epithelial cell differentiation. Under normal circumstances the majority of these infections are self-limiting and cleared by the immune system. However, in rare cases infection can persist and this can ultimately result in the development of malignancy. Two major viral oncoproteins, E6 and E7, are critical for development and maintenance of malignant phenotype. Both of these oncoproteins interfere with crucial cellular pathways that are essential in maintaining cellular homeostasis. These viral activities are necessary for establishing an environment which can support the normal viral life cycle, however when perturbed, can initiate accumulation of changes to the host cell, which can ultimately lead to the development of a malignancy. The importance of E6 and E7 in maintaining transformed cellular phenotype can be clearly observed from the fact that they continue to be expressed in HPV-tumors and derived cells lines numerous years after the primary immortalizing events. This was supported by many studies which showed that any interference with these oncogenes at either the transcriptional or post translational levels results in cell growth arrest and/or apoptosis. Therefore, E6 and E7 represent excellent targets for any therapeutic intervention, and thus the major focus of our current research is on better understanding the molecular mechanisms underlaying their respective functions which could help in developing novel antiviral therapies.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)



POVEZANOST RADA


Projekti:
HRZZ-IP-2016-06-2246 - Rasvjetljivanje onkogenih funkcija E6/E7 HPV-a na različitim anatomskim mjestima (HPVHNC) (Tomaić, Vjekoslav, HRZZ - 2016-06) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Vjekoslav Tomaić (autor)


Citiraj ovu publikaciju

Tomaić, Vjekoslav
Human papillomaviruses: From Infectious Entry to Malignancy // 5. Hrvatski simpozij o prevenciji i liječenju početnog raka vrata maternice s međunarodnim sudjelovanjem
Zagreb, Hrvatska, 2019. str. 2-2 (pozvano predavanje, recenziran, sažetak, znanstveni)
Tomaić, V. (2019) Human papillomaviruses: From Infectious Entry to Malignancy. U: 5. Hrvatski simpozij o prevenciji i liječenju početnog raka vrata maternice s međunarodnim sudjelovanjem.
@article{article, author = {Tomai\'{c}, V.}, year = {2019}, pages = {2-2}, keywords = {HPV, cancer, E6 and E7 oncoproteins}, title = {Human papillomaviruses: From Infectious Entry to Malignancy}, keyword = {HPV, cancer, E6 and E7 oncoproteins}, publisherplace = {Zagreb, Hrvatska} }
@article{article, author = {Tomai\'{c}, V.}, year = {2019}, pages = {2-2}, keywords = {HPV, cancer, E6 and E7 oncoproteins}, title = {Human papillomaviruses: From Infectious Entry to Malignancy}, keyword = {HPV, cancer, E6 and E7 oncoproteins}, publisherplace = {Zagreb, Hrvatska} }




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