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Pregled bibliografske jedinice broj: 1138149

Resolving Issues About Efficacy and Safety of Low-Dose Codeine in Combination Analgesic Drugs: A Systematic Review


Ćelić, Ivan; Bach-Rojecky, Lidija; Merćep, Iveta; Soldo, Ana; Petrak, Anja Kos; Bučan, Ana
Resolving Issues About Efficacy and Safety of Low-Dose Codeine in Combination Analgesic Drugs: A Systematic Review // Pain and Therapy, 9 (2020), 1; 171-194 doi:10.1007/s40122-020-00162-8 (međunarodna recenzija, članak, ostalo)


CROSBI ID: 1138149 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Resolving Issues About Efficacy and Safety of Low-Dose Codeine in Combination Analgesic Drugs: A Systematic Review

Autori
Ćelić, Ivan ; Bach-Rojecky, Lidija ; Merćep, Iveta ; Soldo, Ana ; Petrak, Anja Kos ; Bučan, Ana

Izvornik
Pain and Therapy (2193-8237) 9 (2020), 1; 171-194

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, ostalo

Ključne riječi
Acute pain, Clinical studies, Combination analgesic drugs, Efficacy, Low-dose codeine, Review, Safety, Substance-use disorder

Sažetak
Introduction The objective of this systematic review is to reflect on assumptions in relation to codeine use in combination with other analgesics. Methods MEDLINE was searched according to the predetermined keywords and criteria. Only English language studies were taken into consideration and the outcome data of the final studies were extracted by two reviewers independently from each other and were checked by the third reviewer. Additionally, the available codeine- related Individual Case Safety Reports (ICSRs) retrieved from EudraVigilance were reviewed. Results Sixteen placebo-controlled studies that involved 3378 subjects suffering from acute pain were analyzed for the efficacy of low-dose codeine (≤ 30 mg) combination products. Twelve of them found low-dose codeine combinations more efficient in relieving pain than the assigned comparator. According to 20 randomized clinical trials which included at least one dose of codeine (from 30 to 240 mg daily), the vast majority of reported side-effects were mild or moderate in severity. A total of 20 ICSRs for dependence were identified in the EudraVigilance database with codeine as a suspect drug for the 10-year time period for the European region. Conclusions Low-dose codeine combinations are effective after a single application in treating acute pain. Codeine in doses ≤ 30 mg and higher was considered safe since only mild to moderate side- effects were observed. There is no indication in the available sources which clearly links low doses of codeine to substance use disorder in non-dependent subjects.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Farmacija



POVEZANOST RADA


Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Klinika za psihijatriju Vrapče,
Klinički bolnički centar Zagreb

Profili:

Avatar Url Lidija Bach-Rojecky (autor)

Avatar Url Ivan Ćelić (autor)

doi

Citiraj ovu publikaciju

Ćelić, Ivan; Bach-Rojecky, Lidija; Merćep, Iveta; Soldo, Ana; Petrak, Anja Kos; Bučan, Ana
Resolving Issues About Efficacy and Safety of Low-Dose Codeine in Combination Analgesic Drugs: A Systematic Review // Pain and Therapy, 9 (2020), 1; 171-194 doi:10.1007/s40122-020-00162-8 (međunarodna recenzija, članak, ostalo)
Ćelić, I., Bach-Rojecky, L., Merćep, I., Soldo, A., Petrak, A. & Bučan, A. (2020) Resolving Issues About Efficacy and Safety of Low-Dose Codeine in Combination Analgesic Drugs: A Systematic Review. Pain and Therapy, 9 (1), 171-194 doi:10.1007/s40122-020-00162-8.
@article{article, year = {2020}, pages = {171-194}, DOI = {10.1007/s40122-020-00162-8}, keywords = {Acute pain, Clinical studies, Combination analgesic drugs, Efficacy, Low-dose codeine, Review, Safety, Substance-use disorder}, journal = {Pain and Therapy}, doi = {10.1007/s40122-020-00162-8}, volume = {9}, number = {1}, issn = {2193-8237}, title = {Resolving Issues About Efficacy and Safety of Low-Dose Codeine in Combination Analgesic Drugs: A Systematic Review}, keyword = {Acute pain, Clinical studies, Combination analgesic drugs, Efficacy, Low-dose codeine, Review, Safety, Substance-use disorder} }
@article{article, year = {2020}, pages = {171-194}, DOI = {10.1007/s40122-020-00162-8}, keywords = {Acute pain, Clinical studies, Combination analgesic drugs, Efficacy, Low-dose codeine, Review, Safety, Substance-use disorder}, journal = {Pain and Therapy}, doi = {10.1007/s40122-020-00162-8}, volume = {9}, number = {1}, issn = {2193-8237}, title = {Resolving Issues About Efficacy and Safety of Low-Dose Codeine in Combination Analgesic Drugs: A Systematic Review}, keyword = {Acute pain, Clinical studies, Combination analgesic drugs, Efficacy, Low-dose codeine, Review, Safety, Substance-use disorder} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
    • Emerging Sources Citation Index (ESCI)
  • Scopus


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