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Pregled bibliografske jedinice broj: 1137828

SHH-N non-canonically sustains androgen receptor activity in androgen-independent prostate cancer cells


Trnski, Diana; Sabol, Maja; Tomić, Sanja; Štefanac, Ivan; Mrčela, Milanka; Musani, Vesna; Rinčić, Nikolina; Kurtović, Matea; Petrić, Tina; Levanat, Sonja; Ozretić, Petar
SHH-N non-canonically sustains androgen receptor activity in androgen-independent prostate cancer cells // Scientific reports, 11 (2021), 1; 14880, 11 doi:10.1038/s41598-021-93971-6 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1137828 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
SHH-N non-canonically sustains androgen receptor activity in androgen-independent prostate cancer cells

Autori
Trnski, Diana ; Sabol, Maja ; Tomić, Sanja ; Štefanac, Ivan ; Mrčela, Milanka ; Musani, Vesna ; Rinčić, Nikolina ; Kurtović, Matea ; Petrić, Tina ; Levanat, Sonja ; Ozretić, Petar

Izvornik
Scientific reports (2045-2322) 11 (2021), 1; 14880, 11

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
prostate cancer ; HH-GLI signaling ; SHH-N ; androgen receptor

Sažetak
Prostate cancer is the second most frequent cancer diagnosed in men worldwide. Localized disease can be successfully treated, but advanced cases are more problematic. After initial effectiveness of androgen deprivation therapy, resistance quickly occurs. Therefore, we aimed to investigate the role of Hedgehog-GLI (HH-GLI) signaling in sustaining androgen-independent growth of prostate cancer cells. We found various modes of HH-GLI signaling activation in prostate cancer cells depending on androgen availability. When androgen was not deprived, we found evidence of non-canonical SMO signaling through the SRC kinase. After short-term androgen deprivation canonical HH-GLI signaling was activated, but we found little evidence of canonical HH-GLI signaling activity in androgen-independent prostate cancer cells. We show that in androgen-independent cells the pathway ligand, SHH-N, non-canonically binds to the androgen receptor through its cholesterol modification. Inhibition of this interaction leads to androgen receptor signaling downregulation. This implies that SHH-N activates the androgen receptor and sustains androgen-independence. Targeting this interaction might prove to be a valuable strategy for advanced prostate cancer treatment. Also, other non-canonical aspects of this signaling pathway should be investigated in more detail and considered when developing potential therapies.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
HRZZ-IP-2018-01-2936 - Biološka važnost dipeptidil peptidaze III i njezin utjecaj na zdravlje čovjeka (DPP3BioRe) (Tomić, Sanja, HRZZ - 2018-01) ( POIROT)
HRZZ-IP-2018-01-4889 - Regulacija GLI koda u tumorima ovisnim o BRAF/NRAS mutacijama (GLIcode) (Sabol, Maja, HRZZ - 2018-01) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb,
Klinički bolnički centar Osijek,
Medicinski fakultet, Osijek

Citiraj ovu publikaciju:

Trnski, Diana; Sabol, Maja; Tomić, Sanja; Štefanac, Ivan; Mrčela, Milanka; Musani, Vesna; Rinčić, Nikolina; Kurtović, Matea; Petrić, Tina; Levanat, Sonja; Ozretić, Petar
SHH-N non-canonically sustains androgen receptor activity in androgen-independent prostate cancer cells // Scientific reports, 11 (2021), 1; 14880, 11 doi:10.1038/s41598-021-93971-6 (međunarodna recenzija, članak, znanstveni)
Trnski, D., Sabol, M., Tomić, S., Štefanac, I., Mrčela, M., Musani, V., Rinčić, N., Kurtović, M., Petrić, T., Levanat, S. & Ozretić, P. (2021) SHH-N non-canonically sustains androgen receptor activity in androgen-independent prostate cancer cells. Scientific reports, 11 (1), 14880, 11 doi:10.1038/s41598-021-93971-6.
@article{article, author = {Trnski, Diana and Sabol, Maja and Tomi\'{c}, Sanja and \v{S}tefanac, Ivan and Mr\v{c}ela, Milanka and Musani, Vesna and Rin\v{c}i\'{c}, Nikolina and Kurtovi\'{c}, Matea and Petri\'{c}, Tina and Levanat, Sonja and Ozreti\'{c}, Petar}, year = {2021}, pages = {11}, DOI = {10.1038/s41598-021-93971-6}, chapter = {14880}, keywords = {prostate cancer, HH-GLI signaling, SHH-N, androgen receptor}, journal = {Scientific reports}, doi = {10.1038/s41598-021-93971-6}, volume = {11}, number = {1}, issn = {2045-2322}, title = {SHH-N non-canonically sustains androgen receptor activity in androgen-independent prostate cancer cells}, keyword = {prostate cancer, HH-GLI signaling, SHH-N, androgen receptor}, chapternumber = {14880} }
@article{article, author = {Trnski, Diana and Sabol, Maja and Tomi\'{c}, Sanja and \v{S}tefanac, Ivan and Mr\v{c}ela, Milanka and Musani, Vesna and Rin\v{c}i\'{c}, Nikolina and Kurtovi\'{c}, Matea and Petri\'{c}, Tina and Levanat, Sonja and Ozreti\'{c}, Petar}, year = {2021}, pages = {11}, DOI = {10.1038/s41598-021-93971-6}, chapter = {14880}, keywords = {prostate cancer, HH-GLI signaling, SHH-N, androgen receptor}, journal = {Scientific reports}, doi = {10.1038/s41598-021-93971-6}, volume = {11}, number = {1}, issn = {2045-2322}, title = {SHH-N non-canonically sustains androgen receptor activity in androgen-independent prostate cancer cells}, keyword = {prostate cancer, HH-GLI signaling, SHH-N, androgen receptor}, chapternumber = {14880} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • Social Science Citation Index (SSCI)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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