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Pregled bibliografske jedinice broj: 1137805

Polycationic Monomeric and Homodimeric Asymmetric Monomethine Cyanine Dyes with Hydroxypropyl Functionality—Strong Affinity Nucleic Acids Binders


Mikulin, Ivana; Ljubić, Ivana; Piantanida, Ivo; Vasilev, Aleksey; Mondeshki, Mihail; Kandinska, Meglena; Uzelac, Lidija; Martin-Kleiner, Irena; Kralj, Marijeta; Tumir, Lidija-Marija;
Polycationic Monomeric and Homodimeric Asymmetric Monomethine Cyanine Dyes with Hydroxypropyl Functionality—Strong Affinity Nucleic Acids Binders // Biomolecules, 11 (2021), 8; 1075, 21 doi:10.3390/biom11081075 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1137805 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Polycationic Monomeric and Homodimeric Asymmetric Monomethine Cyanine Dyes with Hydroxypropyl Functionality—Strong Affinity Nucleic Acids Binders

Autori
Mikulin, Ivana ; Ljubić, Ivana ; Piantanida, Ivo ; Vasilev, Aleksey ; Mondeshki, Mihail ; Kandinska, Meglena ; Uzelac, Lidija ; Martin-Kleiner, Irena ; Kralj, Marijeta ; Tumir, Lidija-Marija ;

Izvornik
Biomolecules (2218-273X) 11 (2021), 8; 1075, 21

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
cyanine dye ; DNA binding ; RNA binding ; fluorescence ; circular dichroism ; antiproliferative activity

Sažetak
New analogs of the commercial asymmetric monomethine cyanine dyes thiazole orange (TO) and thiazole orange homodimer (TOTO) with hydroxypropyl functionality were synthesized and their properties in the presence of different nucleic acids were studied. The novel compounds showed strong, micromolar and submicromolar affinities to all examined DNA ds- polynucleotides and poly rA–poly rU. The compounds studied showed selectivity towards GC-DNA base pairs over AT-DNA, which included both binding affinity and a strong fluorescence response. CD titrations showed aggregation along the polynucleotide with well-defined supramolecular chirality. The single dipyridinium-bridged dimer showed intercalation at low dye-DNA/RNA ratios. All new cyanine dyes showed potent micromolar antiproliferative activity against cancer cell lines, making them promising theranostic agents.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Interdisciplinarne prirodne znanosti



POVEZANOST RADA


Projekti:
HRZZ-IP-2018-01-5475 - Višekromoforne probe za prepoznavanje pojedinih struktura DNA, RNA i proteina (BioMultiChromoProbes) (Piantanida, Ivo, HRZZ - 2018-01) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Citiraj ovu publikaciju

Mikulin, Ivana; Ljubić, Ivana; Piantanida, Ivo; Vasilev, Aleksey; Mondeshki, Mihail; Kandinska, Meglena; Uzelac, Lidija; Martin-Kleiner, Irena; Kralj, Marijeta; Tumir, Lidija-Marija;
Polycationic Monomeric and Homodimeric Asymmetric Monomethine Cyanine Dyes with Hydroxypropyl Functionality—Strong Affinity Nucleic Acids Binders // Biomolecules, 11 (2021), 8; 1075, 21 doi:10.3390/biom11081075 (međunarodna recenzija, članak, znanstveni)
Mikulin, I., Ljubić, I., Piantanida, I., Vasilev, A., Mondeshki, M., Kandinska, M., Uzelac, L., Martin-Kleiner, I., Kralj, M., Tumir, L. & (2021) Polycationic Monomeric and Homodimeric Asymmetric Monomethine Cyanine Dyes with Hydroxypropyl Functionality—Strong Affinity Nucleic Acids Binders. Biomolecules, 11 (8), 1075, 21 doi:10.3390/biom11081075.
@article{article, year = {2021}, pages = {21}, DOI = {10.3390/biom11081075}, chapter = {1075}, keywords = {cyanine dye, DNA binding, RNA binding, fluorescence, circular dichroism, antiproliferative activity}, journal = {Biomolecules}, doi = {10.3390/biom11081075}, volume = {11}, number = {8}, issn = {2218-273X}, title = {Polycationic Monomeric and Homodimeric Asymmetric Monomethine Cyanine Dyes with Hydroxypropyl Functionality—Strong Affinity Nucleic Acids Binders}, keyword = {cyanine dye, DNA binding, RNA binding, fluorescence, circular dichroism, antiproliferative activity}, chapternumber = {1075} }
@article{article, year = {2021}, pages = {21}, DOI = {10.3390/biom11081075}, chapter = {1075}, keywords = {cyanine dye, DNA binding, RNA binding, fluorescence, circular dichroism, antiproliferative activity}, journal = {Biomolecules}, doi = {10.3390/biom11081075}, volume = {11}, number = {8}, issn = {2218-273X}, title = {Polycationic Monomeric and Homodimeric Asymmetric Monomethine Cyanine Dyes with Hydroxypropyl Functionality—Strong Affinity Nucleic Acids Binders}, keyword = {cyanine dye, DNA binding, RNA binding, fluorescence, circular dichroism, antiproliferative activity}, chapternumber = {1075} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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