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Pregled bibliografske jedinice broj: 1137607

Composition of the immunoglobulin G glycome associates with the severity of COVID-19


Petrović, Tea; Alves, Inês; Bugada, Dario; Pascual, Julio; Vučković, Frano; Skelin, Andrea; Gaifem, Joana; Villar-Garcia, Judit; Vicente, Manuel M; Fernandes, Ângela et al.
Composition of the immunoglobulin G glycome associates with the severity of COVID-19 // Glycobiology, 31 (2021), 4; 372-377 doi:10.1093/glycob/cwaa102 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1137607 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Composition of the immunoglobulin G glycome associates with the severity of COVID-19

Autori
Petrović, Tea ; Alves, Inês ; Bugada, Dario ; Pascual, Julio ; Vučković, Frano ; Skelin, Andrea ; Gaifem, Joana ; Villar-Garcia, Judit ; Vicente, Manuel M ; Fernandes, Ângela ; Dias, Ana M ; Kurolt, Ivan-Christian ; Markotić, Alemka ; Primorac, Dragan ; Soares, Adriana ; Malheiro, Luis ; Trbojević-Akmačić, Irena ; Abreu, Miguel ; Sarmento E Castro, Rui ; Bettinelli, Silvia ; Callegaro, Annapaola ; Arosio, Marco ; Sangiorgio, Lorena ; Lorini, Luca F ; Castells, Xavier ; Horcajada, Juan P ; Pinho, Salomé S ; Allegri, Massimo ; Barrios, Clara ; Lauc, Gordan

Izvornik
Glycobiology (0959-6658) 31 (2021), 4; 372-377

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
COVID-19 ; IgG glycosylation ; bisecting GlcNAc ; disease biomarkers ; galactosylation

Sažetak
A large variation in the severity of disease symptoms is one of the key open questions in coronavirus disease 2019 (COVID-19) pandemics. The fact that only a small subset of people infected with severe acute respiratory syndrome coronavirus 2 develops severe disease suggests that there have to be some predisposing factors, but biomarkers that reliably predict disease severity have not been found so far. Since overactivation of the immune system is implicated in a severe form of COVID-19 and the immunoglobulin G (IgG) glycosylation is known to be involved in the regulation of different immune processes, we evaluated the association of interindividual variation in IgG N-glycome composition with the severity of COVID-19. The analysis of 166 severe and 167 mild cases from hospitals in Spain, Italy and Portugal revealed statistically significant differences in the composition of the IgG N-glycome. The most notable difference was the decrease in bisecting N-acetylglucosamine in severe patients from all three cohorts. IgG galactosylation was also lower in severe cases in all cohorts, but the difference in galactosylation was not statistically significant after correction for multiple testing.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Interdisciplinarne prirodne znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
EK-EFRR-KK.01.2.2.03.0006 - Centar kompetencija u molekularnoj dijagnostici (CEKOM) (Knjaz, Damir; Lauc, Gordan; Vugrek, Oliver; Polašek, Ozren, EK - KK.01.2.2.03) ( POIROT)
EK-KF-KK.01.1.1.01.0010 - Znanstveni centar izvrsnosti za personaliziranu brigu o zdravlju (ZCIPersonHealth) (Secenji, Aleksandar, EK - KK.01.1.1.01) ( POIROT)
HRZZ-IP-CORONA-IP-CORONA-2020-04-2052 - Glikani kao biomarkeri i funkcionalni efektori teškog oblika COVID-19 (Lauc, Gordan, HRZZ - 2020-04) ( POIROT)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Klinika za infektivne bolesti "Dr Fran Mihaljević",
Medicinski fakultet, Split,
Medicinski fakultet, Osijek,
GENOS d.o.o.,
Specijalna bolnica Sv. Katarina,
Fakultet za dentalnu medicinu i zdravstvo, Osijek

Poveznice na cjeloviti tekst rada:

doi academic.oup.com www.medrxiv.org

Citiraj ovu publikaciju:

Petrović, Tea; Alves, Inês; Bugada, Dario; Pascual, Julio; Vučković, Frano; Skelin, Andrea; Gaifem, Joana; Villar-Garcia, Judit; Vicente, Manuel M; Fernandes, Ângela et al.
Composition of the immunoglobulin G glycome associates with the severity of COVID-19 // Glycobiology, 31 (2021), 4; 372-377 doi:10.1093/glycob/cwaa102 (međunarodna recenzija, članak, znanstveni)
Petrović, T., Alves, I., Bugada, D., Pascual, J., Vučković, F., Skelin, A., Gaifem, J., Villar-Garcia, J., Vicente, M. & Fernandes, Â. (2021) Composition of the immunoglobulin G glycome associates with the severity of COVID-19. Glycobiology, 31 (4), 372-377 doi:10.1093/glycob/cwaa102.
@article{article, author = {Petrovi\'{c}, Tea and Alves, In\^{e}s and Bugada, Dario and Pascual, Julio and Vu\v{c}kovi\'{c}, Frano and Skelin, Andrea and Gaifem, Joana and Villar-Garcia, Judit and Vicente, Manuel M and Fernandes, \^{A}ngela and Dias, Ana M and Kurolt, Ivan-Christian and Markoti\'{c}, Alemka and Primorac, Dragan and Soares, Adriana and Malheiro, Luis and Trbojevi\'{c}-Akma\v{c}i\'{c}, Irena and Abreu, Miguel and Sarmento E Castro, Rui and Bettinelli, Silvia and Callegaro, Annapaola and Arosio, Marco and Sangiorgio, Lorena and Lorini, Luca F and Castells, Xavier and Horcajada, Juan P and Pinho, Salom\'{e} S and Allegri, Massimo and Barrios, Clara and Lauc, Gordan}, year = {2021}, pages = {372-377}, DOI = {10.1093/glycob/cwaa102}, keywords = {COVID-19, IgG glycosylation, bisecting GlcNAc, disease biomarkers, galactosylation}, journal = {Glycobiology}, doi = {10.1093/glycob/cwaa102}, volume = {31}, number = {4}, issn = {0959-6658}, title = {Composition of the immunoglobulin G glycome associates with the severity of COVID-19}, keyword = {COVID-19, IgG glycosylation, bisecting GlcNAc, disease biomarkers, galactosylation} }
@article{article, author = {Petrovi\'{c}, Tea and Alves, In\^{e}s and Bugada, Dario and Pascual, Julio and Vu\v{c}kovi\'{c}, Frano and Skelin, Andrea and Gaifem, Joana and Villar-Garcia, Judit and Vicente, Manuel M and Fernandes, \^{A}ngela and Dias, Ana M and Kurolt, Ivan-Christian and Markoti\'{c}, Alemka and Primorac, Dragan and Soares, Adriana and Malheiro, Luis and Trbojevi\'{c}-Akma\v{c}i\'{c}, Irena and Abreu, Miguel and Sarmento E Castro, Rui and Bettinelli, Silvia and Callegaro, Annapaola and Arosio, Marco and Sangiorgio, Lorena and Lorini, Luca F and Castells, Xavier and Horcajada, Juan P and Pinho, Salom\'{e} S and Allegri, Massimo and Barrios, Clara and Lauc, Gordan}, year = {2021}, pages = {372-377}, DOI = {10.1093/glycob/cwaa102}, keywords = {COVID-19, IgG glycosylation, bisecting GlcNAc, disease biomarkers, galactosylation}, journal = {Glycobiology}, doi = {10.1093/glycob/cwaa102}, volume = {31}, number = {4}, issn = {0959-6658}, title = {Composition of the immunoglobulin G glycome associates with the severity of COVID-19}, keyword = {COVID-19, IgG glycosylation, bisecting GlcNAc, disease biomarkers, galactosylation} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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