Expresion of p53, bcl-2 and growth hormone receptor in actinic keratosis and squamous cell carcinoma of the skin (CROSBI ID 489640)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | domaća recenzija
Podaci o odgovornosti
Stanimirović, Andrija ; Čupić, Hrvoje ; Bošnjak, Berislav ; Krušlin, Božo ; Tomas, Davor ; Belicza, Mladen
engleski
Expresion of p53, bcl-2 and growth hormone receptor in actinic keratosis and squamous cell carcinoma of the skin
According to novel investigations, actinic keratosis (AK) is not a premalignant lesion but is a malignant lesion in the evolution to invasive squamous cell carcinoma (SCC). Thus, we analyzed p53, bcl-2 and growth hormone receptor (GHR) expression in hypertrophic type AK (HAK) to determine the relative importance of these protooncogenes in the biological behavior of HAK. Expression of p53, bcl-2 and GHR was determined by immunohistochemistry in 33 HAK specimens and surrounding perilesional normal skin (PNS). The relative proportions of immunoreactive cells were determined. Of the 33 HAK specimens, 30 (91%) showed immunopositive staining for p53, 33 (100%) for bcl-2 and 12 (36%) for GHR. Highly positive p53 expression in HAK lesions could indicate that p53 mutation is an early and crucial event in lesion development. The detected pattern of the p53/bcl-2 ratio in HAK suggests an important role for another gene: the proapoptotic gene bax. Our findings indicate that GHR expression could be a biological marker of progression of HAK to SCC.
hypertrophic actinic keratosis; p53; bcl-2; growth hormone receptor; immunohistochemistry
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o prilogu
8-10-x.
2003.
objavljeno
Podaci o matičnoj publikaciji
14th Ljudevit Jurak International Symposium on Comparative Pathology, Book of Abstracts
Krušlin, Božo ; Belicza, Mladen
Zagreb: Birotisak
Podaci o skupu
14th Ljudevit Jurak International symposium on comparative pathology
predavanje
06.06.2003-07.06.2003
Zagreb, Hrvatska