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Pregled bibliografske jedinice broj: 1137327

P53/p73 Protein Network in Colorectal Cancer and Other Human Malignancies


Horvat, Anđela; Tadijan, Ana; Vlašić, Ignacija; Slade, Neda
p53/p73 Protein Network in Colorectal Cancer and Other Human Malignancies // Cancers, 13 (2021), 12; 2885, 42 doi:10.3390/cancers13122885 (međunarodna recenzija, članak, znanstveni)


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Naslov
P53/p73 Protein Network in Colorectal Cancer and Other Human Malignancies

Autori
Horvat, Anđela ; Tadijan, Ana ; Vlašić, Ignacija ; Slade, Neda

Izvornik
Cancers (2072-6694) 13 (2021), 12; 2885, 42

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
p53 isoforms ; p73 isoforms ; colorectal cancer ; p53 family ; isoform crosstalk

Sažetak
The p53 tumor suppressor protein is crucial for cell growth control and the maintenance of genomic stability. Later discovered, p63 and p73 share structural and functional similarity with p53. To understand the p53 pathways more profoundly, all family members should be considered. Each family member possesses two promoters and alternative translation initiation sites, and they undergo alternative splicing, generating multiple isoforms. The resulting isoforms have important roles in carcinogenesis, while their expression is dysregulated in several human tumors including colorectal carcinoma, which makes them potential targets in cancer treatment. Their activities arise, at least in part, from the ability to form tetramers that bind to specific DNA sequences and activate the transcription of target genes. In this review, we summarize the current understanding of the biological activities and regulation of the p53/p73 isoforms, highlighting their role in colorectal tumorigenesis. The analysis of the expression patterns of the p53/p73 isoforms in human cancers provides an important step in the improvement of cancer therapy. Furthermore, the interactions among the p53 family members which could modulate normal functions of the canonical p53 in tumor tissue are described. Lastly, we emphasize the importance of clinical studies to assess the significance of combining the deregulation of different members of the p53 family to define the outcome of the disease.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
IP-2013-11-1615 - Otkrivanje novih proteinskih interakcija kao podloga za nove pristupe liječenju melanoma čovjeka (ProNetMel) (Slade, Neda, HRZZ - 2013-11) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Neda Slade (autor)

Avatar Url Ignacija Vlašić (autor)

Avatar Url Ana Tadijan (autor)

Avatar Url Anđela Horvat (autor)

Poveznice na cjeloviti tekst rada:

doi www.mdpi.com www.ncbi.nlm.nih.gov fulir.irb.hr

Citiraj ovu publikaciju:

Horvat, Anđela; Tadijan, Ana; Vlašić, Ignacija; Slade, Neda
p53/p73 Protein Network in Colorectal Cancer and Other Human Malignancies // Cancers, 13 (2021), 12; 2885, 42 doi:10.3390/cancers13122885 (međunarodna recenzija, članak, znanstveni)
Horvat, A., Tadijan, A., Vlašić, I. & Slade, N. (2021) p53/p73 Protein Network in Colorectal Cancer and Other Human Malignancies. Cancers, 13 (12), 2885, 42 doi:10.3390/cancers13122885.
@article{article, author = {Horvat, An\djela and Tadijan, Ana and Vla\v{s}i\'{c}, Ignacija and Slade, Neda}, year = {2021}, pages = {42}, DOI = {10.3390/cancers13122885}, chapter = {2885}, keywords = {p53 isoforms, p73 isoforms, colorectal cancer, p53 family, isoform crosstalk}, journal = {Cancers}, doi = {10.3390/cancers13122885}, volume = {13}, number = {12}, issn = {2072-6694}, title = {p53/p73 Protein Network in Colorectal Cancer and Other Human Malignancies}, keyword = {p53 isoforms, p73 isoforms, colorectal cancer, p53 family, isoform crosstalk}, chapternumber = {2885} }
@article{article, author = {Horvat, An\djela and Tadijan, Ana and Vla\v{s}i\'{c}, Ignacija and Slade, Neda}, year = {2021}, pages = {42}, DOI = {10.3390/cancers13122885}, chapter = {2885}, keywords = {p53 isoforms, p73 isoforms, colorectal cancer, p53 family, isoform crosstalk}, journal = {Cancers}, doi = {10.3390/cancers13122885}, volume = {13}, number = {12}, issn = {2072-6694}, title = {p53/p73 Protein Network in Colorectal Cancer and Other Human Malignancies}, keyword = {p53 isoforms, p73 isoforms, colorectal cancer, p53 family, isoform crosstalk}, chapternumber = {2885} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


Citati:





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