Yeast extract demonstrates rapid itch relief in chronic pruritus (CROSBI ID 296822)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Zhang, Y. ; Tan, Y. ; Zou, Y. ; Bulat V. ; Lugovic Mihic, L ; Kovacevic, M. ; Lotti, T. ; Verner, I. ; Stanimirovic, A. ; Šitum, M. ; Goldust, M. ; Liu, W. ; Vojvodic, A. ; Goren. A.
engleski
Yeast extract demonstrates rapid itch relief in chronic pruritus
Background: Pruritus is the most common complaint encountered in dermatological practice. It is estimated that up to 4% of the world population suffers from chronic itch. Chronic pruritus can be associated with both cutaneous or systemic conditions. While a plethora of treatments attempt to address itch, most carry risk of significant adverse events with chronic use ; thus, there exists an unmet need to develop safe treatments for chronic pruritus. A recent study demonstrated that a novel extract from Saccharomyces cerevisiae, that is, Baker's yeast, blocks various histamine receptors as well as inhibits numerous inflammatory cytokines. Methods: Given the long- term safety profile of Baker's yeast, we set to investigate the efficacy of the novel extract in the treatment of chronic pruritus. Key results: In our study, we demonstrated that within 30 minutes, the novel extract significantly reduced itch when compared to a placebo lotion (P = .0020). Conclusions: To our knowledge, this is the first study demonstrating that a novel extract from Saccharomyces cerevisiae can provide rapid and sustained itch relief to chronic pruritus patients.
chronic ; pruritis ; yeast.
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Podaci o izdanju
19 (8)
2020.
2131-2134
objavljeno
1473-2130
1473-2165
10.1111/jocd.13265
Povezanost rada
Temeljne medicinske znanosti