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Pregled bibliografske jedinice broj: 1136985

MiR-182-5p and miR-375-3p Have Higher Performance Than PSA in Discriminating Prostate Cancer from Benign Prostate Hyperplasia


Abramovic, Irena; Vrhovec, Borna; Skara, Lucija; Vrtaric, Alen; Nikolac Gabaj, Nora; Kulis, Tomislav; Stimac, Goran; Ljiljak, Dejan; Ruzic, Boris; Kastelan, Zeljko et al.
MiR-182-5p and miR-375-3p Have Higher Performance Than PSA in Discriminating Prostate Cancer from Benign Prostate Hyperplasia // Cancers, 13 (2021), 9; 2068, 13 doi:10.3390/cancers13092068 (međunarodna recenzija, članak, znanstveni)


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Naslov
MiR-182-5p and miR-375-3p Have Higher Performance Than PSA in Discriminating Prostate Cancer from Benign Prostate Hyperplasia

Autori
Abramovic, Irena ; Vrhovec, Borna ; Skara, Lucija ; Vrtaric, Alen ; Nikolac Gabaj, Nora ; Kulis, Tomislav ; Stimac, Goran ; Ljiljak, Dejan ; Ruzic, Boris ; Kastelan, Zeljko ; Kruslin, Bozo ; Bulic-Jakus, Floriana ; Ulamec, Monika ; Katusic-Bojanac, Ana ; Sincic, Nino

Izvornik
Cancers (2072-6694) 13 (2021), 9; 2068, 13

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
prostate cancer ; microRNA ; liquid biopsy ; biomarkers ; benign prostate hyperplasia ; plasma ; seminal fluid

Sažetak
Rostate cancer (PCa) is the most prevalent neoplasia among men worldwide but is commonly “mimicked” by benign prostate hyperplasia (BPH). Their discrimination by the prostate- specific antigen (PSA) is often uncertain, resulting in lengthy diagnostic protocols and recurrent tissue biopsies. The development of more appropriate biomarkers, possibly present in liquid biopsy, would significantly improve PCa and BPH patient management. To address this challenge, in this study miR-375-3p, miR-182- 5p, miR-21-5p, and miR-148a-3p were analyzed by ddPCR in blood plasma and seminal plasma of patients with PCa and BPH prior to tissue biopsy. Among other findings, miR-182-5p and miR-375-3p were found to have statistically significantly higher expression in PCa patients compared to BPH in blood, with a combined specificity of 90.2% to predict positive or negative biopsy results. The data presented emphasize the great potential of miRNAs as liquid biopsy biomarkers for PCa.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
UIP-2017-05-8138 - Epigenetički biomarkeri raka prostate (epiPro) (Sinčić, Nino, HRZZ - 2017-05) ( POIROT)

Ustanove:
Medicinski fakultet, Zagreb

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Abramovic, Irena; Vrhovec, Borna; Skara, Lucija; Vrtaric, Alen; Nikolac Gabaj, Nora; Kulis, Tomislav; Stimac, Goran; Ljiljak, Dejan; Ruzic, Boris; Kastelan, Zeljko et al.
MiR-182-5p and miR-375-3p Have Higher Performance Than PSA in Discriminating Prostate Cancer from Benign Prostate Hyperplasia // Cancers, 13 (2021), 9; 2068, 13 doi:10.3390/cancers13092068 (međunarodna recenzija, članak, znanstveni)
Abramovic, I., Vrhovec, B., Skara, L., Vrtaric, A., Nikolac Gabaj, N., Kulis, T., Stimac, G., Ljiljak, D., Ruzic, B. & Kastelan, Z. (2021) MiR-182-5p and miR-375-3p Have Higher Performance Than PSA in Discriminating Prostate Cancer from Benign Prostate Hyperplasia. Cancers, 13 (9), 2068, 13 doi:10.3390/cancers13092068.
@article{article, author = {Abramovic, Irena and Vrhovec, Borna and Skara, Lucija and Vrtaric, Alen and Nikolac Gabaj, Nora and Kulis, Tomislav and Stimac, Goran and Ljiljak, Dejan and Ruzic, Boris and Kastelan, Zeljko and Kruslin, Bozo and Bulic-Jakus, Floriana and Ulamec, Monika and Katusic-Bojanac, Ana and Sincic, Nino}, year = {2021}, pages = {13}, DOI = {10.3390/cancers13092068}, chapter = {2068}, keywords = {prostate cancer, microRNA, liquid biopsy, biomarkers, benign prostate hyperplasia, plasma, seminal fluid}, journal = {Cancers}, doi = {10.3390/cancers13092068}, volume = {13}, number = {9}, issn = {2072-6694}, title = {MiR-182-5p and miR-375-3p Have Higher Performance Than PSA in Discriminating Prostate Cancer from Benign Prostate Hyperplasia}, keyword = {prostate cancer, microRNA, liquid biopsy, biomarkers, benign prostate hyperplasia, plasma, seminal fluid}, chapternumber = {2068} }
@article{article, author = {Abramovic, Irena and Vrhovec, Borna and Skara, Lucija and Vrtaric, Alen and Nikolac Gabaj, Nora and Kulis, Tomislav and Stimac, Goran and Ljiljak, Dejan and Ruzic, Boris and Kastelan, Zeljko and Kruslin, Bozo and Bulic-Jakus, Floriana and Ulamec, Monika and Katusic-Bojanac, Ana and Sincic, Nino}, year = {2021}, pages = {13}, DOI = {10.3390/cancers13092068}, chapter = {2068}, keywords = {prostate cancer, microRNA, liquid biopsy, biomarkers, benign prostate hyperplasia, plasma, seminal fluid}, journal = {Cancers}, doi = {10.3390/cancers13092068}, volume = {13}, number = {9}, issn = {2072-6694}, title = {MiR-182-5p and miR-375-3p Have Higher Performance Than PSA in Discriminating Prostate Cancer from Benign Prostate Hyperplasia}, keyword = {prostate cancer, microRNA, liquid biopsy, biomarkers, benign prostate hyperplasia, plasma, seminal fluid}, chapternumber = {2068} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


Citati:





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