engleski

Four Nutrients - Enriched Hen Eggs Consumption Improves Skin Microvascular Reactivity in Healthy Individuals

Introduction: In addition to basic nutrients necessary for the growth and development of the organism, functional food also contains ingredients that improve health or reduce the risk of developing chronic diseases1. Recently we demonstrated that consumption of hen eggs enriched with n-3 polyunsaturated fatty acids (n-3 PUFAs) improves microvascular blood flow2, 3. The aim of this study was to determine the effect of four nutrients - enriched hen eggs (n-3 PUFA, lutein, vitamin E and selenium) on microvascular reactivity in healthy young subjects4. Material and Methods: Healthy young subjects of both sexes were divided into two groups, control group (N = 9, consumed 3 regular eggs) and Quatro group (N = 14, consumed 3 enriched eggs) in morning, daily, for three weeks. Endothelium-dependent vasodilation to iontophoretically administered acetylcholine (ACh) and to post-occlusive reactive hyperemia (PORH) and iontoforetically administered sodium-nitroprusside ((SNP) ; measure of endothelium-independent vasodilatation) were assessed by Laser Doppler Flowmetry. Vascular reactivity in microcirculation was assessed on the first and last day of dietary protocol1. Results: Vasodilation in response to ACh and PORH was significantly enhanced after dietary protocol within Quatro group. Response to SNP remained unchanged in both groups. Conclusions: Consumption of hen eggs enriched with 4 nutrients improved microcirculatory blood flow in response to acetylcholine and reactive hyperemia in young healthy subjects. Since serum concentration of n-3 PUFAs was significantly higher in the group of subjects who consumed eggs enriched with four nutrients, results suggest beneficial effects of functional food consumption in microcirculation. Acknowledgments: The author would like to thank all the members from the group Department of Physiology and Immunology, Faculty of Medicine Osijek. Financial Support: The research is funded by the Croatian National Science Center of Excellence for Personalized Health Care, Josip Juraj Strossmayer University Osijek # KK.01.1.1.01.0010. Conflict of Interest: None. Authorship: Conceptualization, P.Š., A.S. and I.D. ; methodology, P.Š., A.S., N.K., Z.M., and I.D. ; software, P.Š., A.S. and I.D., ; validation, P.Š., A.S., I.D. ; formal analysis, P.Š., A.S. and I.D. ; investigation, P.Š. N.K., Z.M. and A.S. ; resources, I.D. ; writing, P.Š., and N.K. ; Z.M., A.S. and I.D. ; visualization, P.Š., A.S. and I.D. ; supervision, I.D. ; project administration, P.Š., A.S. and I.D. ; funding acquisition, I.D.

endothelium dependent and independent vasodilation ; functional food ; microvascular reactivity ; n-3 PUFAs

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