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Transient subplate sublayer forms unique corridor for differential ingrowth of associative pulvinar and primary visual projection in the prospective visual cortical areas of the human fetal occipital lobe (CROSBI ID 296728)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Žunić Išasegi, Iris ; Kopić, Janja ; Smilović, Dinko ; Krsnik, Željka ; Kostović, Ivica Transient subplate sublayer forms unique corridor for differential ingrowth of associative pulvinar and primary visual projection in the prospective visual cortical areas of the human fetal occipital lobe // Cerebral cortex, 32 (2021), 1; 110-122. doi: 10.1093/cercor/bhab197

Podaci o odgovornosti

Žunić Išasegi, Iris ; Kopić, Janja ; Smilović, Dinko ; Krsnik, Željka ; Kostović, Ivica

engleski

Transient subplate sublayer forms unique corridor for differential ingrowth of associative pulvinar and primary visual projection in the prospective visual cortical areas of the human fetal occipital lobe

Cytoarchitectonical parcellation of the visual cortex into the striate and extrastriate cortex requires complex histogenetic events within a precise spatio-temporal frame to attain the specification of areal domains and associated thalamocortical connections during the fetal brain development. We analyzed a deep subplate cellular monolayer (subplate “corridor” cells) present during a restricted period of 13–15 postconceptional weeks, showing the 3D caudo-ventro-medial position in the human fetal occipital lobe, corresponding to the segregation point of pulvinocortical and geniculocortical fibers at the prospective area 17/18 border. Immunofluorescence stainings revealed subplate “corridor” cells as the specific class of the deepest subplate neurons (NeuN+, Tbr1+, Cplx3+) expressing axon guidance molecules (Sema-3A+, EphA6+), presumably for the attraction of pulvinocortical axons and the repulsion of geniculocortical axons growing at that time (SNAP25+, Syn+, FN+). Furthermore, quantitative analysis of the subplate “corridor” region of interest, considering cell number, immunofluorescence signal intensity per cell and per region, revealed significant differences to other regions across the tangential circumference of the developing cerebral wall. Thus, our study sheds new light on the deepest subplate sublayer, strategically aligned along the growing axon systems in the prospective visual system, suggesting the establishment of the area 17/18 border by differential thalamocortical input during the fetal brain development.

axon navigation ; cytoarhitectonic ; fetal human brain ; prospective visual cortex ; subplate

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Podaci o izdanju

32 (1)

2021.

110-122

objavljeno

1047-3211

1460-2199

10.1093/cercor/bhab197

Povezanost rada

nije evidentirano

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