engleski

Biocompatible composite materials for bone tissue engineering application

Tissue damage and organ failure caused by defects, injuries and diseases represent one of the major problems in human health care. The shortage of available donor organs and effect of immunological rejection of foreign tissue complicate transplantation procedures. Autologous mesenchymal stem cells (MSCs) from bone marrow and fat are well-suited for cell-therapy treatment and have been recently used. Development of potential tissue substituent is focused on biocompatibility, biodegradability, bioactivity and minimal immunological reaction. Those properties can be achieved using biodegradable and bioactive materials. In our previous studies, we have proved the versatility of chitosan-based and hydroxyapatite-based materials as scaffolds that significantly support bone formation during short stem cells culture. Furthermore, the biological activity of those scaffolds has been improved by incorporating different therapeutic ions which are involved in main processes of bone formation and regeneration. Our next goals include functionalization of former materials in terms of mechanical stability and tissue regeneration. Future aspects of our research will cover the production of biodegradable 3D supports for bone augmentation and chemistry modification for faster tissue vascularization and targeted neotissue growth.

biodegradable ; composite ; chitosan ; hydroxyapatite ; bone tissue engineering

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