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Pregled bibliografske jedinice broj: 1135878

Analysis and occurrence of macrolide residues in stream sediments and underlying alluvial aquifer downstream from a pharmaceutical plant


Senta, Ivan; Terzić, Senka; Ahel, Marijan
Analysis and occurrence of macrolide residues in stream sediments and underlying alluvial aquifer downstream from a pharmaceutical plant // Environmental Pollution, 273 (2021), 116433, 10 doi:10.1016/j.envpol.2021.116433 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1135878 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Analysis and occurrence of macrolide residues in stream sediments and underlying alluvial aquifer downstream from a pharmaceutical plant

Autori
Senta, Ivan ; Terzić, Senka ; Ahel, Marijan

Izvornik
Environmental Pollution (0269-7491) 273 (2021); 116433, 10

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Antibiotics ; Azithromycin ; Groundwater ; Erythromycin ; Transformation products

Sažetak
Macrolide antibiotics azithromycin (AZI), erythromycin (ERY) and clarithromycin (CLA) have been recently included in the EU Watch List of contaminants of emerging concern in the aquatic environment. However, their comprehensive assessment in different environmental compartments, by including synthesis intermediates, by-products and transformation products, is still missing. In this work, a novel method, based on pressurized liquid extraction and liquid chromatographyetandem mass spectrometry, was developed and validated for the determination of such an extended range of macrolide residues in sediment and soil samples at low ng/g levels. The method was applied to determine distribution of 13 macrolides in surface and alluvial aquifer sediments collected in a small stream with a history of chronic exposure to wastewater discharges from AZI production. The total concentrations of the target macrolide compounds in surface sediments were up to 29 mg/g and the most prominent individual macrolides were parent AZI, its synthesis intermediate N-demethyl AZI and transformation products decladinosyl AZI and N0-demethyl AZI. Some ERY-related compounds, originating from AZI synthesis, were also frequently detected, though at lower concentration levels (up to 0.31 ng/g in total). The distribution of macrolide residues in surface sediments indicated their active longitudinal transport by resuspension and redeposition of the contaminated sediment particles. The vertical concentration profiles in stream sediments and the underlying alluvial aquifer revealed that macrolide residues reached deeper alluvial sediments (up to 5 m). Moreover, significant levels of macrolides were found in groundwater samples below the streambed, with the total concentrations reaching up to 1.7 mg/L. This study highlights the importance of comprehensive chemical characterization of the macrolide residues, which were shown to persist in surface and alluvial aquifer sediment more than ten years after their discharge into the aquatic environment.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Interdisciplinarne prirodne znanosti



POVEZANOST RADA


Projekti:
HRZZ-IP-2019-04-9519 - Istraživanje farmaceutskog ekspozoma slatkovodnih organizama - procjena rizika i prioritizacija (PHARMA-RISK) (Terzić, Senka, HRZZ - 2019-04) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Marijan Ahel (autor)

Avatar Url Senka Terzić (autor)

Avatar Url Ivan Senta (autor)

Poveznice na cjeloviti tekst rada:

doi apps.webofknowledge.com www.sciencedirect.com

Citiraj ovu publikaciju:

Senta, Ivan; Terzić, Senka; Ahel, Marijan
Analysis and occurrence of macrolide residues in stream sediments and underlying alluvial aquifer downstream from a pharmaceutical plant // Environmental Pollution, 273 (2021), 116433, 10 doi:10.1016/j.envpol.2021.116433 (međunarodna recenzija, članak, znanstveni)
Senta, I., Terzić, S. & Ahel, M. (2021) Analysis and occurrence of macrolide residues in stream sediments and underlying alluvial aquifer downstream from a pharmaceutical plant. Environmental Pollution, 273, 116433, 10 doi:10.1016/j.envpol.2021.116433.
@article{article, author = {Senta, Ivan and Terzi\'{c}, Senka and Ahel, Marijan}, year = {2021}, pages = {10}, DOI = {10.1016/j.envpol.2021.116433}, chapter = {116433}, keywords = {Antibiotics, Azithromycin, Groundwater, Erythromycin, Transformation products}, journal = {Environmental Pollution}, doi = {10.1016/j.envpol.2021.116433}, volume = {273}, issn = {0269-7491}, title = {Analysis and occurrence of macrolide residues in stream sediments and underlying alluvial aquifer downstream from a pharmaceutical plant}, keyword = {Antibiotics, Azithromycin, Groundwater, Erythromycin, Transformation products}, chapternumber = {116433} }
@article{article, author = {Senta, Ivan and Terzi\'{c}, Senka and Ahel, Marijan}, year = {2021}, pages = {10}, DOI = {10.1016/j.envpol.2021.116433}, chapter = {116433}, keywords = {Antibiotics, Azithromycin, Groundwater, Erythromycin, Transformation products}, journal = {Environmental Pollution}, doi = {10.1016/j.envpol.2021.116433}, volume = {273}, issn = {0269-7491}, title = {Analysis and occurrence of macrolide residues in stream sediments and underlying alluvial aquifer downstream from a pharmaceutical plant}, keyword = {Antibiotics, Azithromycin, Groundwater, Erythromycin, Transformation products}, chapternumber = {116433} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati:





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