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Pregled bibliografske jedinice broj: 1135398

New Insights into the Diagnosis, Molecular Taxonomy, and Treatment of Bladder Cancer


Ulamec, Monika; Murgić, Jure; Novosel, Luka; Tomić, Miroslav; Terlević, Robert; Tomašković, Igor; Jazvić, Marijana; Fröbe, Ana; Krušlin, Božo
New Insights into the Diagnosis, Molecular Taxonomy, and Treatment of Bladder Cancer // Acta Medica Academica, 50 (2021), 16; 143-156 doi:10.5644/ama2006-124.332 (međunarodna recenzija, članak, znanstveni)


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Naslov
New Insights into the Diagnosis, Molecular Taxonomy, and Treatment of Bladder Cancer

Autori
Ulamec, Monika ; Murgić, Jure ; Novosel, Luka ; Tomić, Miroslav ; Terlević, Robert ; Tomašković, Igor ; Jazvić, Marijana ; Fröbe, Ana ; Krušlin, Božo

Izvornik
Acta Medica Academica (1840-1848) 50 (2021), 16; 143-156

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Bladder Cancer Pathology ; Bladder Cancer Therapy ; Bladder Cancer Genetics.

Sažetak
This review aims to emphasize new insights into the diagnosis, classification, and therapy of bladder cancer (BC). Bladder cancer is a heterogeneous, complex disease on a morphological, molecular, diagnostic, and prognostic level. Cancer stage is still the most important attribute for prognosis and treatment, while early detection with optimal and rapid individual therapeutic and surveillance approach is crucial. The vast majority of patients have a superficial, non-muscle-invasive tumor associated with a good prognosis after resection and adjuvant intravesical maintenance immuno or chemotherapy if needed. On the other hand, muscle-invasive bladder cancer is a highly aggressive disease with high morbidity and mortality. However, it has become a model for oncology success over the last five years with many available targeted therapeutic modalities. Metastatic BC is now amenable to multimodal treatment combining cystectomy and neoadjuvant chemotherapy and immunotherapy and is a target for precision medicine. Conclusion. A new molecular taxonomy for bladder cancer has been proposed and provided insight into BC’s carcinogenesis, with some possible effects on therapy decisions. However, this classification is still not applicable in routine clinical practice. It opens new questions regarding the interplay between tumor genetic signature, intratumoral hetero-geneity, therapy implications, and tumor progression

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)



POVEZANOST RADA


Ustanove:
Stomatološki fakultet, Zagreb,
Medicinski fakultet, Zagreb,
KBC "Sestre Milosrdnice",
Opća bolnica Pula,
Medicinski fakultet, Osijek,
Sveučilište u Zagrebu

Profili:

Avatar Url Monika Ulamec (autor)

Avatar Url Ana Fröbe (autor)

Avatar Url Igor Tomašković (autor)

Avatar Url Božo Krušlin (autor)

Avatar Url Jure Murgić (autor)

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Ulamec, Monika; Murgić, Jure; Novosel, Luka; Tomić, Miroslav; Terlević, Robert; Tomašković, Igor; Jazvić, Marijana; Fröbe, Ana; Krušlin, Božo
New Insights into the Diagnosis, Molecular Taxonomy, and Treatment of Bladder Cancer // Acta Medica Academica, 50 (2021), 16; 143-156 doi:10.5644/ama2006-124.332 (međunarodna recenzija, članak, znanstveni)
Ulamec, M., Murgić, J., Novosel, L., Tomić, M., Terlević, R., Tomašković, I., Jazvić, M., Fröbe, A. & Krušlin, B. (2021) New Insights into the Diagnosis, Molecular Taxonomy, and Treatment of Bladder Cancer. Acta Medica Academica, 50 (16), 143-156 doi:10.5644/ama2006-124.332.
@article{article, year = {2021}, pages = {143-156}, DOI = {10.5644/ama2006-124.332}, keywords = {Bladder Cancer Pathology, Bladder Cancer Therapy, Bladder Cancer Genetics.}, journal = {Acta Medica Academica}, doi = {10.5644/ama2006-124.332}, volume = {50}, number = {16}, issn = {1840-1848}, title = {New Insights into the Diagnosis, Molecular Taxonomy, and Treatment of Bladder Cancer}, keyword = {Bladder Cancer Pathology, Bladder Cancer Therapy, Bladder Cancer Genetics.} }
@article{article, year = {2021}, pages = {143-156}, DOI = {10.5644/ama2006-124.332}, keywords = {Bladder Cancer Pathology, Bladder Cancer Therapy, Bladder Cancer Genetics.}, journal = {Acta Medica Academica}, doi = {10.5644/ama2006-124.332}, volume = {50}, number = {16}, issn = {1840-1848}, title = {New Insights into the Diagnosis, Molecular Taxonomy, and Treatment of Bladder Cancer}, keyword = {Bladder Cancer Pathology, Bladder Cancer Therapy, Bladder Cancer Genetics.} }

Časopis indeksira:


  • Scopus
  • MEDLINE


Citati:





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