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Pregled bibliografske jedinice broj: 1135237

Nuclear Ubiquitin-Proteasome Pathways in Proteostasis Maintenance


Franić, Dina; Zubčić, Klara; Boban, Mirta
Nuclear Ubiquitin-Proteasome Pathways in Proteostasis Maintenance // Biomolecules, 11 (2021), 1; 1-16 doi:10.3390/biom11010054 (međunarodna recenzija, članak, znanstveni)


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Naslov
Nuclear Ubiquitin-Proteasome Pathways in Proteostasis Maintenance

Autori
Franić, Dina ; Zubčić, Klara ; Boban, Mirta

Izvornik
Biomolecules (2218-273X) 11 (2021), 1; 1-16

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
inner nuclear membrane ; nucleus ; proteasome ; protein misfolding ; protein quality control ; proteostasis ; ubiquitin ; yeast

Sažetak
Protein homeostasis, or proteostasis, is crucial for the functioning of a cell, as proteins that are mislocalized, present in excessive amounts, or aberrant due to misfolding or other type of damage can be harmful. Proteostasis includes attaining the correct protein structure, localization, and the formation of higher order complexes, and well as the appropriate protein concentrations. Consequences of proteostasis imbalance are evident in a range of neurodegenerative diseases characterized by protein misfolding and aggregation, such as Alzheimer's, Parkinson's, and amyotrophic lateral sclerosis. To protect the cell from the accumulation of aberrant proteins, a network of protein quality control (PQC) pathways identifies the substrates and direct them towards refolding or elimination via regulated protein degradation. The main pathway for degradation of misfolded proteins is the ubiquitin-proteasome system. PQC pathways have been first described in the cytoplasm and the endoplasmic reticulum, however, accumulating evidence indicates that the nucleus is an important PQC compartment for ubiquitination and proteasomal degradation of not only nuclear, but also cytoplasmic proteins. In this review, we summarize the nuclear ubiquitin- proteasome pathways involved in proteostasis maintenance in yeast, focusing on inner nuclear membrane-associated degradation (INMAD) and San1- mediated protein quality control.

Izvorni jezik
Engleski



POVEZANOST RADA


Projekti:
HRZZ-PZS-2019-02-3610 - Kontrola kvalitete proteina putem selektivne razgradnje u stanicama u mirovanju (Q-CTRL) (Boban, Mirta, HRZZ ) ( CroRIS)

Ustanove:
Medicinski fakultet, Zagreb,
Sveučilište u Zagrebu

Profili:

Avatar Url Dina Franić (autor)

Avatar Url Klara Zubčić (autor)

Avatar Url Mirta Boban (autor)

Poveznice na cjeloviti tekst rada:

doi www.mdpi.com www.mdpi.com

Citiraj ovu publikaciju:

Franić, Dina; Zubčić, Klara; Boban, Mirta
Nuclear Ubiquitin-Proteasome Pathways in Proteostasis Maintenance // Biomolecules, 11 (2021), 1; 1-16 doi:10.3390/biom11010054 (međunarodna recenzija, članak, znanstveni)
Franić, D., Zubčić, K. & Boban, M. (2021) Nuclear Ubiquitin-Proteasome Pathways in Proteostasis Maintenance. Biomolecules, 11 (1), 1-16 doi:10.3390/biom11010054.
@article{article, author = {Frani\'{c}, Dina and Zub\v{c}i\'{c}, Klara and Boban, Mirta}, year = {2021}, pages = {1-16}, DOI = {10.3390/biom11010054}, keywords = {inner nuclear membrane, nucleus, proteasome, protein misfolding, protein quality control, proteostasis, ubiquitin, yeast}, journal = {Biomolecules}, doi = {10.3390/biom11010054}, volume = {11}, number = {1}, issn = {2218-273X}, title = {Nuclear Ubiquitin-Proteasome Pathways in Proteostasis Maintenance}, keyword = {inner nuclear membrane, nucleus, proteasome, protein misfolding, protein quality control, proteostasis, ubiquitin, yeast} }
@article{article, author = {Frani\'{c}, Dina and Zub\v{c}i\'{c}, Klara and Boban, Mirta}, year = {2021}, pages = {1-16}, DOI = {10.3390/biom11010054}, keywords = {inner nuclear membrane, nucleus, proteasome, protein misfolding, protein quality control, proteostasis, ubiquitin, yeast}, journal = {Biomolecules}, doi = {10.3390/biom11010054}, volume = {11}, number = {1}, issn = {2218-273X}, title = {Nuclear Ubiquitin-Proteasome Pathways in Proteostasis Maintenance}, keyword = {inner nuclear membrane, nucleus, proteasome, protein misfolding, protein quality control, proteostasis, ubiquitin, yeast} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati:





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