Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 1134891

Sex-related response in mice after sub-acute intraperitoneal exposure to silver nanoparticles


Tariba Lovaković, Blanka; Barbir, Rinea; Pem, Barbara; Goessler, Walter; Ćurlin, Marija; Micek, Vedran; Debeljak, Željko; Božičević, Lucija; Ilić, Krunoslav; Pavičić, Ivan et al.
Sex-related response in mice after sub-acute intraperitoneal exposure to silver nanoparticles // NanoImpact, 23 (2021), 100340, 13 doi:10.1016/j.impact.2021.100340 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1134891 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Sex-related response in mice after sub-acute intraperitoneal exposure to silver nanoparticles

Autori
Tariba Lovaković, Blanka ; Barbir, Rinea ; Pem, Barbara ; Goessler, Walter ; Ćurlin, Marija ; Micek, Vedran ; Debeljak, Željko ; Božičević, Lucija ; Ilić, Krunoslav ; Pavičić, Ivan ; Gorup, Dunja ; Vinković Vrček, Ivana

Izvornik
NanoImpact (2452-0748) 23 (2021); 100340, 13

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
biodistribution ; oxidative stress ; steroid hormones ; transferrin ; poly(vinyl)pyrrolidone

Sažetak
Silver nanoparticles (AgNPs) are among the most commercialized nanomaterials in biomedicine due to their antimicrobial and anti-inflammatory properties. Nevertheless, possible health hazards of exposure to AgNPs are yet to be understood and therefore raise public concern in regards of their safety. In this study, sex-related differences, role of steroidal hormones and influence of two different surface stabilizing agents (polymer vs. protein) on distribution and adverse effects of AgNPs were investigated in vivo. Intact and gonadectomised male and female mice were treated with seven AgNPs doses administered intraperitoneally during 21 days. After treatment, steroid hormone levels in serum, accumulation of Ag levels and oxidative stress biomarkers in liver, kidneys, brain and lungs were determined. Sex-related differences were observed in almost all tissues. Concentration of Ag was significantly higher in the liver of females compared to males. No significant difference was found for AgNP accumulation in lungs between females and males, while the lungs of intact males showed significantly higher Ag accumulation compared to gonadectomised group. Effect of surface coating was also observed, as Ag accumulation was significantly higher in kidneys and liver of intact females, as well as in kidneys and brain of intact males treated with protein-coated AgNPs compared to polymeric AgNPs. Oxidative stress response to AgNPs was the most pronounced in kidneys where protein-coated AgNPs induced stronger effects compared to polymeric AgNPs. Interestingly, protein-coated AgNPs reduced generation of reactive oxygen species in brains of females and gonadectomised males. Although there were no significant differences in levels of hormones in the AgNP-exposed animals compared to controls, sex-related differences in oxidative stress parameters were observed in all organs. Results of this study highlight the importance of including the sex-related differences and effects of protein corona in biosafety evaluation of AgNPs exposure.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Interdisciplinarne prirodne znanosti, Farmacija



POVEZANOST RADA


Projekti:
IP-2016-06-2436 - Značaj interakcija metalnih nanočestica sa sumpornim biomolekulama za nano-bio sučelje (NanoFaceS) (Vinković Vrček, Ivana, HRZZ - 2016-06) ( POIROT)

Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Medicinski fakultet, Zagreb,
Klinički bolnički centar Osijek,
Medicinski fakultet, Osijek

Citiraj ovu publikaciju

Tariba Lovaković, Blanka; Barbir, Rinea; Pem, Barbara; Goessler, Walter; Ćurlin, Marija; Micek, Vedran; Debeljak, Željko; Božičević, Lucija; Ilić, Krunoslav; Pavičić, Ivan et al.
Sex-related response in mice after sub-acute intraperitoneal exposure to silver nanoparticles // NanoImpact, 23 (2021), 100340, 13 doi:10.1016/j.impact.2021.100340 (međunarodna recenzija, članak, znanstveni)
Tariba Lovaković, B., Barbir, R., Pem, B., Goessler, W., Ćurlin, M., Micek, V., Debeljak, Ž., Božičević, L., Ilić, K. & Pavičić, I. (2021) Sex-related response in mice after sub-acute intraperitoneal exposure to silver nanoparticles. NanoImpact, 23, 100340, 13 doi:10.1016/j.impact.2021.100340.
@article{article, year = {2021}, pages = {13}, DOI = {10.1016/j.impact.2021.100340}, chapter = {100340}, keywords = {biodistribution, oxidative stress, steroid hormones, transferrin, poly(vinyl)pyrrolidone}, journal = {NanoImpact}, doi = {10.1016/j.impact.2021.100340}, volume = {23}, issn = {2452-0748}, title = {Sex-related response in mice after sub-acute intraperitoneal exposure to silver nanoparticles}, keyword = {biodistribution, oxidative stress, steroid hormones, transferrin, poly(vinyl)pyrrolidone}, chapternumber = {100340} }
@article{article, year = {2021}, pages = {13}, DOI = {10.1016/j.impact.2021.100340}, chapter = {100340}, keywords = {biodistribution, oxidative stress, steroid hormones, transferrin, poly(vinyl)pyrrolidone}, journal = {NanoImpact}, doi = {10.1016/j.impact.2021.100340}, volume = {23}, issn = {2452-0748}, title = {Sex-related response in mice after sub-acute intraperitoneal exposure to silver nanoparticles}, keyword = {biodistribution, oxidative stress, steroid hormones, transferrin, poly(vinyl)pyrrolidone}, chapternumber = {100340} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


Citati





    Contrast
    Increase Font
    Decrease Font
    Dyslexic Font