hrvatski

Utjecaj odabranih ksenobiotika na boju urina

Use of any xenobiotic can result in adverse effects which are often results of the effects of xenobiotic itself, its metabolites and complexes with endobiotics. Adverse effects can sometimes be serious, even life­ threatening, and sometimes completely harmless. One type of adverse effects is change of urine colour after application of some xenobiotics. Urine colour change due to the xenobiotics application can be result of the colour of xenobio­ tic itself or the colour of its metabolites. Possible metabolic reactions that can result in urine discoloration include different oxidoreductions, mostly catalysed by cytochrome 450 enzymes, different conjugations, bacterial reactions, pho­ tolysis, complexation of metal cations and even chemical reaction with urinary catheter. Even though these adverse effects are mostly harmless, patients often develop fear and discomfort which can lead to reduced adherence in case of some drugs. Therefore, education of patients as well as health professionals about possible urine colour change after application of some xenobiotics is of importance. In this paper, effects of selected xenobiotics on the urine colour and their biochemical basis are given.

lijekovi ; metabolizam ; urin

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