Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 1133700

Effects of estradiol on biological age measured using the glycan age index


Jurić, Julija; Kohrt, Wendy M.; Kifer, Domagoj; Gavin, Kathleen M; Pezer, Marija; Nigrovic, Peter A.; Lauc, Gordan
Effects of estradiol on biological age measured using the glycan age index // Aging-US, 12 (2020), 19; 19756-19765 doi:10.18632/aging.104060 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1133700 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Effects of estradiol on biological age measured using the glycan age index

Autori
Jurić, Julija ; Kohrt, Wendy M. ; Kifer, Domagoj ; Gavin, Kathleen M ; Pezer, Marija ; Nigrovic, Peter A. ; Lauc, Gordan

Izvornik
Aging-US (1945-4589) 12 (2020), 19; 19756-19765

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
aging biomarkers ; biological age ; estrogen ; glycan age ; glycosylation

Sažetak
Glycan age is a recently developed biomarker based on glycans attached to immunoglobulin G (IgG). In large population cohorts, glycan age associates well with lifestyle and disease-risk biomarkers, while some studies suggested that glycan changes precede development of several age-associated diseases. In this study we evaluated effects of estrogen on the glycan age. Gonadal hormones were suppressed in 36 healthy young women by gonadotropin releasing hormone agonist therapy for 6 months. In 15 of them estradiol was supplemented, while 21 received placebo resulting in very low estrogen levels during intervention. IgG was isolated from plasma samples before intervention, after 6 months of intervention and after subsequent 4- month recovery. Deprivation of gonadal hormones resulted in median increase of glycan age for 9.1 years (IQR 6.8 – 11.5 years, p = 3.73×10-8), which was completely prevented by transdermal estradiol therapy (change in glycan age = -0.23 years, IQR (-2.20 – 2.98). After the recovery period glycan age returned to baseline values in both groups. These results suggest that IgG glycans and consequently also the glycan age are under strong influence of gonadal hormones and that estradiol therapy can prevent the increase of glycan age that occurs in the perimenopausal period.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
EK-EFRR-KK.01.2.2.03.0006 - Centar kompetencija u molekularnoj dijagnostici (CEKOM) (Knjaz, Damir; Lauc, Gordan; Vugrek, Oliver; Polašek, Ozren, EK - KK.01.2.2.03) ( POIROT)
EK-EFRR-KK.01.2.1.01.0003 - Nova generacija visokošprotočnih glikoservisa (Lauc, Gordan; Gornik Kljaić, Olga; Zoldoš, Vlatka, EK - Poziv na dostavu projektnih prijedloga „Povećanje razvoja novih proizvoda i usluga koji proizlaze iz aktivnosti istraživanja i razvoja“) ( POIROT)
EK-KF-KK.01.1.1.01.0010 - ZCI za personaliziranu brigu o zdravlju (ZCIPersonHealth) (Secenji, Aleksandar, EK ) ( POIROT)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
GENOS d.o.o.

Profili:

Avatar Url Julija Jurić (autor)

Avatar Url Marija Pezer (autor)

Avatar Url Domagoj Kifer (autor)

Avatar Url Gordan Lauc (autor)

Citiraj ovu publikaciju

Jurić, Julija; Kohrt, Wendy M.; Kifer, Domagoj; Gavin, Kathleen M; Pezer, Marija; Nigrovic, Peter A.; Lauc, Gordan
Effects of estradiol on biological age measured using the glycan age index // Aging-US, 12 (2020), 19; 19756-19765 doi:10.18632/aging.104060 (međunarodna recenzija, članak, znanstveni)
Jurić, J., Kohrt, W., Kifer, D., Gavin, K., Pezer, M., Nigrovic, P. & Lauc, G. (2020) Effects of estradiol on biological age measured using the glycan age index. Aging-US, 12 (19), 19756-19765 doi:10.18632/aging.104060.
@article{article, year = {2020}, pages = {19756-19765}, DOI = {10.18632/aging.104060}, keywords = {aging biomarkers, biological age, estrogen, glycan age, glycosylation}, journal = {Aging-US}, doi = {10.18632/aging.104060}, volume = {12}, number = {19}, issn = {1945-4589}, title = {Effects of estradiol on biological age measured using the glycan age index}, keyword = {aging biomarkers, biological age, estrogen, glycan age, glycosylation} }
@article{article, year = {2020}, pages = {19756-19765}, DOI = {10.18632/aging.104060}, keywords = {aging biomarkers, biological age, estrogen, glycan age, glycosylation}, journal = {Aging-US}, doi = {10.18632/aging.104060}, volume = {12}, number = {19}, issn = {1945-4589}, title = {Effects of estradiol on biological age measured using the glycan age index}, keyword = {aging biomarkers, biological age, estrogen, glycan age, glycosylation} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati





    Contrast
    Increase Font
    Decrease Font
    Dyslexic Font