The Association of Cardiovascular Disease with the T3111C Polymorphism in the CLOCK Gene (CROSBI ID 704556)
Prilog sa skupa u zborniku | stručni rad | međunarodna recenzija
Podaci o odgovornosti
Škrlec, Ivana ; Talapko, Jasminka ; Džijan, Snježana ; Lepeduš, Hrvoje
engleski
The Association of Cardiovascular Disease with the T3111C Polymorphism in the CLOCK Gene
Cardiovascular diseases (CVDs) are among the leading causes of death worldwide, although CVDs mortality has decreased in developed countries. Numerous pathophysiological processes lead to the development of CVDs. The circadian rhythm coordinates many physiological processes, and its disruption can lead to many pathophysiological changes. One of the significant circadian rhythm genes is the CLOCK gene, whose polymorphisms are associated with CVD risk factors. Research findings of the association between CLOCK gene polymorphism and CVDs and its comorbidities are not consistent. This meta- analysis was conducted to quantify the associations between T3111C polymorphism and the risk of CVDs. The PubMed and Scopus databases were searched for studies reporting on the association between T3111C (rs1801260) in the circadian CLOCK gene and cardiovascular disease and its comorbidities such as obesity, hypertension, insulin resistance, and coronary artery disease. A fixed-effect model was used to calculate the pooled odds ratio and 95% confidence interval by comprehensive meta- analysis software. Five independent studies, including case-control, cross- sectional, and cohort research methods, were analyzed with 3, 123 subjects in total. The meta-analysis revealed a significant association between T3111C polymorphism and cardiovascular disease (OR = 1.32, 95% CI: 1.16–1.50, p < 0.001) with significant heterogeneity (I2 = 91.1%, p < 0.001) and no publication bias. The subgroup analysis on comorbidity related to CVDs revealed that hypertension was associated with T3111C polymorphism (OR = 2.02, 95% CI: 1.60– 2.54, p < 0.001). Our meta-analysis based on available studies using a fixed model shows that T3111C polymorphism in the CLOCK gene is associated with CVDs susceptibility.
CLOCK gene ; cardiovascular disease ; hypertension ; obesity ; T3111C polymorphism
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Podaci o prilogu
1-7.
2021.
objavljeno
10.3390/IECMD2021-10314
Podaci o matičnoj publikaciji
Medical Sciences Forum
Basel: MDPI Books
2673-9992
2673-9992
Podaci o skupu
1st International Electronic Conference on Medicine (IECMD 2021)
predavanje
20.06.2021-30.06.2021
online