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Pregled bibliografske jedinice broj: 1133457

Renal Cell Carcinoma With Leiomyomatous Stroma: A Group of Tumors With Indistinguishable Histopathologic Features, But 2 Distinct Genetic Profiles: Next-Generation Sequencing Analysis of 6 Cases Negative for Aberrations Related to the VHL gene


Petersson, Fredrik; Martinek, Petr; Vanecek, Tomas; Pivovarcikova, Kristyna; Peckova, Kvetoslava; Ondic, Ondrej; Perez-Montiel, Delia; Skenderi, Faruk; Ulamec, Monika; Nenutil, Rudolf et al.
Renal Cell Carcinoma With Leiomyomatous Stroma: A Group of Tumors With Indistinguishable Histopathologic Features, But 2 Distinct Genetic Profiles: Next-Generation Sequencing Analysis of 6 Cases Negative for Aberrations Related to the VHL gene // Applied Immunohistochemistry & Molecular Morphology, 26 (2018), 3; 192-197 doi:10.1097/pai.0000000000000410 (međunarodna recenzija, članak, ostalo)


CROSBI ID: 1133457 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Renal Cell Carcinoma With Leiomyomatous Stroma: A Group of Tumors With Indistinguishable Histopathologic Features, But 2 Distinct Genetic Profiles: Next-Generation Sequencing Analysis of 6 Cases Negative for Aberrations Related to the VHL gene

Autori
Petersson, Fredrik ; Martinek, Petr ; Vanecek, Tomas ; Pivovarcikova, Kristyna ; Peckova, Kvetoslava ; Ondic, Ondrej ; Perez-Montiel, Delia ; Skenderi, Faruk ; Ulamec, Monika ; Nenutil, Rudolf ; Hora, Milan ; Svoboda, Tomas ; Rotterova, Pavla ; Dusek, Martin ; Michal, Michal ; Hes, Ondrej

Izvornik
Applied Immunohistochemistry & Molecular Morphology (1541-2016) 26 (2018), 3; 192-197

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, ostalo

Ključne riječi
kidney ; renal cell carcinoma with leiomyomatous stroma ; clear cell papillary renal cell carcinoma ; TCEB1 mutated renal carcinoma ; next-generation sequencing

Sažetak
We have studied a cohort of renal cell carcinomas (RCCs) with smooth-muscle stroma (N=6), which lacked any of following genetic aberrations: mutations in the VHL-gene-coding sequence, loss of heterozygosity of chromosome 3p, or hypermethylation of VHL. Using targeted next- generation sequencing, no intronic VHL mutations or mutations in selected genes involved in angiogenesis and genes frequently mutated in clear cell RCC were identified. Tumors were also tested for the presence of hotspot mutations in the TCEB1 gene with negative results in all cases. We conclude that there exists a group of RCCs with abundant leiomyomatous stroma, where the epithelial component is indistinguishable from conventional clear cell RCC and distinct from clear cell (tubulo-) papillary RCC and that these tumors lack aberrations related to the function of the VHL gene, mutations in genes involved in angiogenesis, and hotspot mutations in the TCEB1 gene.

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)



POVEZANOST RADA


Profili:

Avatar Url Monika Ulamec (autor)

Avatar Url Faruk Skenderi (autor)

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Petersson, Fredrik; Martinek, Petr; Vanecek, Tomas; Pivovarcikova, Kristyna; Peckova, Kvetoslava; Ondic, Ondrej; Perez-Montiel, Delia; Skenderi, Faruk; Ulamec, Monika; Nenutil, Rudolf et al.
Renal Cell Carcinoma With Leiomyomatous Stroma: A Group of Tumors With Indistinguishable Histopathologic Features, But 2 Distinct Genetic Profiles: Next-Generation Sequencing Analysis of 6 Cases Negative for Aberrations Related to the VHL gene // Applied Immunohistochemistry & Molecular Morphology, 26 (2018), 3; 192-197 doi:10.1097/pai.0000000000000410 (međunarodna recenzija, članak, ostalo)
Petersson, F., Martinek, P., Vanecek, T., Pivovarcikova, K., Peckova, K., Ondic, O., Perez-Montiel, D., Skenderi, F., Ulamec, M. & Nenutil, R. (2018) Renal Cell Carcinoma With Leiomyomatous Stroma: A Group of Tumors With Indistinguishable Histopathologic Features, But 2 Distinct Genetic Profiles: Next-Generation Sequencing Analysis of 6 Cases Negative for Aberrations Related to the VHL gene. Applied Immunohistochemistry & Molecular Morphology, 26 (3), 192-197 doi:10.1097/pai.0000000000000410.
@article{article, year = {2018}, pages = {192-197}, DOI = {10.1097/pai.0000000000000410}, keywords = {kidney, renal cell carcinoma with leiomyomatous stroma, clear cell papillary renal cell carcinoma, TCEB1 mutated renal carcinoma, next-generation sequencing}, journal = {Applied Immunohistochemistry and Molecular Morphology}, doi = {10.1097/pai.0000000000000410}, volume = {26}, number = {3}, issn = {1541-2016}, title = {Renal Cell Carcinoma With Leiomyomatous Stroma: A Group of Tumors With Indistinguishable Histopathologic Features, But 2 Distinct Genetic Profiles: Next-Generation Sequencing Analysis of 6 Cases Negative for Aberrations Related to the VHL gene}, keyword = {kidney, renal cell carcinoma with leiomyomatous stroma, clear cell papillary renal cell carcinoma, TCEB1 mutated renal carcinoma, next-generation sequencing} }
@article{article, year = {2018}, pages = {192-197}, DOI = {10.1097/pai.0000000000000410}, keywords = {kidney, renal cell carcinoma with leiomyomatous stroma, clear cell papillary renal cell carcinoma, TCEB1 mutated renal carcinoma, next-generation sequencing}, journal = {Applied Immunohistochemistry and Molecular Morphology}, doi = {10.1097/pai.0000000000000410}, volume = {26}, number = {3}, issn = {1541-2016}, title = {Renal Cell Carcinoma With Leiomyomatous Stroma: A Group of Tumors With Indistinguishable Histopathologic Features, But 2 Distinct Genetic Profiles: Next-Generation Sequencing Analysis of 6 Cases Negative for Aberrations Related to the VHL gene}, keyword = {kidney, renal cell carcinoma with leiomyomatous stroma, clear cell papillary renal cell carcinoma, TCEB1 mutated renal carcinoma, next-generation sequencing} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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