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Pregled bibliografske jedinice broj: 1133400

Interplay between immunity and amyotrophic lateral sclerosis: Clinical impact


De Marchi, Fabiola; Munitic, Ivana; Amedei, Amedeo; Berry, James D.; Feldman, Eva L.; Aronica, Eleonora; Nardo, Giovanni; Van Weehaeghe, Donatienne; Niccolai, Elena; Prtenjaca, Nikolina et al.
Interplay between immunity and amyotrophic lateral sclerosis: Clinical impact // Neuroscience & Biobehavioral Reviews, 127 (2021), 958-978 doi:10.1016/j.neubiorev.2021.06.027 (međunarodna recenzija, pregledni rad, znanstveni)


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Naslov
Interplay between immunity and amyotrophic lateral sclerosis: Clinical impact

Autori
De Marchi, Fabiola ; Munitic, Ivana ; Amedei, Amedeo ; Berry, James D. ; Feldman, Eva L. ; Aronica, Eleonora ; Nardo, Giovanni ; Van Weehaeghe, Donatienne ; Niccolai, Elena ; Prtenjaca, Nikolina ; Sakowski, Stacey A. ; Bendotti, Caterina ; Mazzini, Letizia

Izvornik
Neuroscience & Biobehavioral Reviews (0149-7634) 127 (2021); 958-978

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
amyotrophic lateral sclerosis ; biomarkers ; immunity ; inflammation ; target ; targeted therapies.

Sažetak
Amyotrophic lateral sclerosis (ALS) is a debilitating and rapidly fatal neurodegenerative disease. Despite decades of research and many new insights into disease biology over the 150 years since the disease was first described, causative pathogenic mechanisms in ALS remain poorly understood, especially in sporadic cases. Our understanding of the role of the immune system in ALS pathophysiology, however, is rapidly expanding. The aim of this manuscript is to summarize the recent advances regarding the immune system involvement in ALS, with particular attention to clinical translation. We focus on the potential pathophysiologic mechanism of the immune system in ALS, discussing local and systemic factors (blood, cerebrospinal fluid, and microbiota) that influence ALS onset and progression in animal models and people. We also explore the potential of Positron Emission Tomography to detect neuroinflammation in vivo, and discuss ongoing clinical trials of therapies targeting the immune system. With validation in human patients, new evidence in this emerging field will serve to identify novel therapeutic targets and provide realistic hope for personalized treatment strategies.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)



POVEZANOST RADA


Projekti:
HRZZ-IP-2018-01-8563 - Kontrola neurodegeneracije moduliranjem sprege između upale i proteinopatije (ImmunoModifyCNS) (Munitić, Ivana, HRZZ - 2018-01) ( POIROT)

Ustanove:
Sveučilište u Rijeci - Odjel za biotehnologiju

Profili:

Avatar Url Nikolina Prtenjača (autor)

Avatar Url Ivana Munitić (autor)

Poveznice na cjeloviti tekst rada:

doi pubmed.ncbi.nlm.nih.gov

Citiraj ovu publikaciju:

De Marchi, Fabiola; Munitic, Ivana; Amedei, Amedeo; Berry, James D.; Feldman, Eva L.; Aronica, Eleonora; Nardo, Giovanni; Van Weehaeghe, Donatienne; Niccolai, Elena; Prtenjaca, Nikolina et al.
Interplay between immunity and amyotrophic lateral sclerosis: Clinical impact // Neuroscience & Biobehavioral Reviews, 127 (2021), 958-978 doi:10.1016/j.neubiorev.2021.06.027 (međunarodna recenzija, pregledni rad, znanstveni)
De Marchi, F., Munitic, I., Amedei, A., Berry, J., Feldman, E., Aronica, E., Nardo, G., Van Weehaeghe, D., Niccolai, E. & Prtenjaca, N. (2021) Interplay between immunity and amyotrophic lateral sclerosis: Clinical impact. Neuroscience & Biobehavioral Reviews, 127, 958-978 doi:10.1016/j.neubiorev.2021.06.027.
@article{article, year = {2021}, pages = {958-978}, DOI = {10.1016/j.neubiorev.2021.06.027}, keywords = {amyotrophic lateral sclerosis, biomarkers, immunity, inflammation, target, targeted therapies.}, journal = {Neuroscience and Biobehavioral Reviews}, doi = {10.1016/j.neubiorev.2021.06.027}, volume = {127}, issn = {0149-7634}, title = {Interplay between immunity and amyotrophic lateral sclerosis: Clinical impact}, keyword = {amyotrophic lateral sclerosis, biomarkers, immunity, inflammation, target, targeted therapies.} }
@article{article, year = {2021}, pages = {958-978}, DOI = {10.1016/j.neubiorev.2021.06.027}, keywords = {amyotrophic lateral sclerosis, biomarkers, immunity, inflammation, target, targeted therapies.}, journal = {Neuroscience and Biobehavioral Reviews}, doi = {10.1016/j.neubiorev.2021.06.027}, volume = {127}, issn = {0149-7634}, title = {Interplay between immunity and amyotrophic lateral sclerosis: Clinical impact}, keyword = {amyotrophic lateral sclerosis, biomarkers, immunity, inflammation, target, targeted therapies.} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati:





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