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Pregled bibliografske jedinice broj: 1133398

Salivary melatonin in oral squamous cell carcinoma patients


Salarić, Ivan; Karmelić, Ivana; Lovrić, Jasna; Baždarić, Ksenija; Rožman, Marko; Čvrljević, Igor; Zajc, Ivan; Brajdić, Davor; Macan, Darko
Salivary melatonin in oral squamous cell carcinoma patients // Scientific reports, 11 (2021), 13201, 9 doi:10.1038/s41598-021-92649-3 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1133398 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Salivary melatonin in oral squamous cell carcinoma patients

Autori
Salarić, Ivan ; Karmelić, Ivana ; Lovrić, Jasna ; Baždarić, Ksenija ; Rožman, Marko ; Čvrljević, Igor ; Zajc, Ivan ; Brajdić, Davor ; Macan, Darko

Izvornik
Scientific reports (2045-2322) 11 (2021); 13201, 9

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Melatonin, Salivary ; Oral cancer ; Circadian rhythm ; Sleep quality

Sažetak
Melatonin’s role in circadian rhythm is well documented, as are its’ anti-oxidant, oncostatic and antiinflammatory properties. Poor sleep quality has been associated as a potential risk factor for several malignancies, including head and neck cancers. The purpose of this study is to determine salivary melatonin (MLT) levels in oral squamous cell carcinoma (OSCC) patients, compare the salivary MLT levels with those in healthy individuals and compare the salivary and serum levels in OSCC patients. Furthermore, the aim is to investigate the potential relationship between sleep quality and salivary MLT levels in OSCC patients. Unstimulated (UWS) and stimulated (SWS) whole saliva was sampled from patients with T1N0M0 and T2N0M0 OSCC (N = 34) and 33 sex and age matched healthy subjects. Serum samples were taken from 11 OSCC patients. Sleep quality was measured using Pittsburgh Sleep Quality Index (PSQI) questionnaire. Melatonin levels in UWS and SWS were significantly higher in the OSCC group. Sleep quality was significantly lower in patients with OSCC (P = 0.0001). ROC analysis was found to be significant (P < 0.001) in evaluating MLT concentration limit in diagnosing OSCC. The expected relationship between sleep quality and salivary MLT levels in OSCC patients was not observed. Our results suggest salivary MLT as a potential biomarker that might facilitate non- invasive detection of early stage OSCC.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti, Kliničke medicinske znanosti, Dentalna medicina



POVEZANOST RADA


Projekti:
HRZZ-IP-2014-09-9376 - Izolacija, kvantifikacija i kinetika salivarnih Ap4A, SCCA i TROP2 kod pacijenata s oralnim karcinomom i potencijalno malignim poremećajima (OC Sal TM) (Macan, Darko, HRZZ - 2014-09) ( POIROT)

Ustanove:
Medicinski fakultet, Rijeka,
Stomatološki fakultet, Zagreb,
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb,
Klinička bolnica "Dubrava"

Poveznice na cjeloviti tekst rada:

doi www.nature.com doi.org fulir.irb.hr

Citiraj ovu publikaciju:

Salarić, Ivan; Karmelić, Ivana; Lovrić, Jasna; Baždarić, Ksenija; Rožman, Marko; Čvrljević, Igor; Zajc, Ivan; Brajdić, Davor; Macan, Darko
Salivary melatonin in oral squamous cell carcinoma patients // Scientific reports, 11 (2021), 13201, 9 doi:10.1038/s41598-021-92649-3 (međunarodna recenzija, članak, znanstveni)
Salarić, I., Karmelić, I., Lovrić, J., Baždarić, K., Rožman, M., Čvrljević, I., Zajc, I., Brajdić, D. & Macan, D. (2021) Salivary melatonin in oral squamous cell carcinoma patients. Scientific reports, 11, 13201, 9 doi:10.1038/s41598-021-92649-3.
@article{article, author = {Salari\'{c}, Ivan and Karmeli\'{c}, Ivana and Lovri\'{c}, Jasna and Ba\v{z}dari\'{c}, Ksenija and Ro\v{z}man, Marko and \v{C}vrljevi\'{c}, Igor and Zajc, Ivan and Brajdi\'{c}, Davor and Macan, Darko}, year = {2021}, pages = {9}, DOI = {10.1038/s41598-021-92649-3}, chapter = {13201}, keywords = {Melatonin, Salivary, Oral cancer, Circadian rhythm, Sleep quality}, journal = {Scientific reports}, doi = {10.1038/s41598-021-92649-3}, volume = {11}, issn = {2045-2322}, title = {Salivary melatonin in oral squamous cell carcinoma patients}, keyword = {Melatonin, Salivary, Oral cancer, Circadian rhythm, Sleep quality}, chapternumber = {13201} }
@article{article, author = {Salari\'{c}, Ivan and Karmeli\'{c}, Ivana and Lovri\'{c}, Jasna and Ba\v{z}dari\'{c}, Ksenija and Ro\v{z}man, Marko and \v{C}vrljevi\'{c}, Igor and Zajc, Ivan and Brajdi\'{c}, Davor and Macan, Darko}, year = {2021}, pages = {9}, DOI = {10.1038/s41598-021-92649-3}, chapter = {13201}, keywords = {Melatonin, Salivary, Oral cancer, Circadian rhythm, Sleep quality}, journal = {Scientific reports}, doi = {10.1038/s41598-021-92649-3}, volume = {11}, issn = {2045-2322}, title = {Salivary melatonin in oral squamous cell carcinoma patients}, keyword = {Melatonin, Salivary, Oral cancer, Circadian rhythm, Sleep quality}, chapternumber = {13201} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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