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Nonaqueous Polyethylene Glycol as a Safer Alternative to Ethanolic Propolis Extracts with Comparable Antioxidant and Antimicrobial Activity (CROSBI ID 295904)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Šuran, Jelena ; Cepanec, Ivica ; Mašek, Tomislav ; Starčević, Kristina ; Tlak Gajger, Ivana ; Vranješ, Mihaela ; Radić, Božo ; Radić, Saša ; Kosalec, Ivan ; Vlainić, Josipa Nonaqueous Polyethylene Glycol as a Safer Alternative to Ethanolic Propolis Extracts with Comparable Antioxidant and Antimicrobial Activity // Antioxidants, 10 (2021), 6; 978, 13. doi: 10.3390/antiox10060978

Podaci o odgovornosti

Šuran, Jelena ; Cepanec, Ivica ; Mašek, Tomislav ; Starčević, Kristina ; Tlak Gajger, Ivana ; Vranješ, Mihaela ; Radić, Božo ; Radić, Saša ; Kosalec, Ivan ; Vlainić, Josipa

engleski

Nonaqueous Polyethylene Glycol as a Safer Alternative to Ethanolic Propolis Extracts with Comparable Antioxidant and Antimicrobial Activity

We compared the chemical composition, antioxidant and antimicrobial activity of two propolis extracts: one obtained with nonaqueous polyethylene glycol, PEG 400 (PgEP), and the other obtained with ethanol (EEP). We analyzed the total phenolic content (TPC) and the concentrations of ten markers of propolis antioxidant activity with HPLC-UV: caffeic acid, p-coumaric acid, trans-ferulic acid, trans-cinnamic acid, kaempferol, apigenin, pinocembrin, chrysin, CAPE, and galangin. Antioxidant activity was tested using DPPH and FRAP assay, and antimicrobial activity was assessed through minimum inhibitory concentrations (MICs) and minimum biofilm eradication concentration (MBEC) determination. Maceration gave the yield of propolis of 25.2 ± 0.08% in EEP, and 21.5 ± 0.24% in PgEP. All ten markers of antioxidant activity were found in both extracts, with all marker concentrations, except kaempferol, higher in EEP. There was no significant difference between the TPC and antioxidant activity of the PgEP and the EEP extract ; TPC of PgEP was 16.78 ± 0.23 mg/mL, while EEP had TPC of 15.92 ± 0.78 mg/mL. Both extracts had antimicrobial activity against most investigated pathogens and Staphylococcus aureus, Acinetobacter baumannii, and Escherichia coli biofilms. EEP was more effective against all tested susceptible pathogens, except E. coli, possibly due to higher content of kaempferol in PgEP relative to other polyphenols. Nonaqueous PEG 400 could be used for propolis extraction. It gives extracts with comparable concentrations of antioxidants and has a good antioxidant and antimicrobial activity. It is a safe excipient, convenient for pediatric and veterinary formulations.

propolis ; extracts ; ethanol ; PEG400 ; antioxidant activity ; antimicrobial activity

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Podaci o izdanju

10 (6)

2021.

978

13

objavljeno

2076-3921

10.3390/antiox10060978

Povezanost rada

Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje), Interdisciplinarne prirodne znanosti, Kemija, Temeljne medicinske znanosti, Veterinarska medicina

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