engleski

Susceptibility to antimicrobial agents of Streptococcus suis capsular type 2 strains isolated from pigs.

The minimal inhibitory concentrations (MICs) for thirty-three epidemiologicaly unrelated clinical isolates of Streptococcus suis capsular type 2 were determined in relation to ampicillin, ampicillin-sulbactam, amoxicillin, clavulanate- amoxicillin, penicillin G, cephalexin, gentamicin, streptomycin, erythromycin, tylosin and doxycycline, using the microtitre broth dilution procedures described by the U.S, . National Committee for Clinical Laboratory Standards (NCCLS). Gentamicin was the most active compound tested, with an MIC for 90percent of the strains tested (MIC90)of 0.4 mg/L. Overal, 70 percent of strains were resistant to doxycyclin, followed by penicillin G (51 percent of strains. Resistance to amoxicillin and ampicillin was 36.4 percent and 33.3 percent, respectively. 15.2 percent of S. suis strains were resistant to streptomycin, tylosin and cephalexin with MIC90 values of 25.0 mg/L, 12.5 mg/L and 25.0 mg/L, respectively. A combination of ampicillin and sulbactam (MIC 90 6.3 mg/L) and combination of amoxicillin and clavulanate (MIC90 3.1 mg/L) as well as erythromycin (1.6 mg/L) were of the same efficacy, with a total of 9.1 percent resistant S. suis strains. This high percentage of resistance to doxycycline and penicillin G precludes the use of these antibiotics as empiric therapy of swine diseases.

Netherlands ; Resistance ; Infections

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