The association of essential metals with APOE genotype in Alzheimer's disease (CROSBI ID 295500)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Babić Leko, Mirjana ; Jurasović, Jasna ; Nikolac Perković, Matea ; Španić, Ena ; Sekovanić, Ankica ; Orct, Tatjana ; Lukinović Škudar, Vesna ; Bačić Baronica, Koraljka ; Kiđemet-Piskač, Spomenka ; Vogrinc, Željka ; Pivac, Nela ; Borovečki, Fran ; Hof, Patrick R. ; Šimić, Goran
engleski
The association of essential metals with APOE genotype in Alzheimer's disease
Background: The major confirmed genetic risk factor for late-onset, sporadic Alzheimer's disease (AD) is variant ɛ4 of apolipoprotein E gene (APOE). It is proposed that ApoE, a protein involved in transport of cholesterol to neurons can cause neurodegeneration in AD through interaction with metals. Previous studies mostly associated copper, iron, zinc, and calcium with ApoE4-mediated toxicity. Objective: To test the association of essential metals with APOE genotype. Methods: We compared plasma and cerebrospinal fluid (CSF) levels of copper, zinc, iron, sodium, magnesium, calcium, cobalt, molybdenum, manganese, boron, and chromium, and CSF ferritin levels among AD, mild cognitive impairment (MCI) patients, and healthy controls (HC) with different APOE genotype. Results: Sodium, copper, and magnesium levels were increased in carriers of ɛ4 allele. Additionally, the increase in sodium, calcium and cobalt plasma levels was observed in carriers of ɛ4/ɛx genotype. The decrease in boron plasma levels was observed in carriers of ɛ4 allele and ɛ4/ɛ4 genotype. Additionally, CSF zinc levels as well as plasma sodium levels were increased in AD patients compared to HC. Conclusion: These results indicate that the molecular underpinnings of association of essential metals and metalloids with APOE should be further tested and clarified in vivo and in vitro.
Alzheimer’s disease ; apolipoprotein E ; copper ; metals ; mild cognitive impairment ; zinc
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nije evidentirano
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Podaci o izdanju
82 (2)
2021.
661-672
objavljeno
1387-2877
1875-8908
10.3233/JAD-210158
Povezanost rada
Biologija, Kliničke medicinske znanosti, Kognitivna znanost (prirodne, tehničke, biomedicina i zdravstvo, društvene i humanističke znanosti), Psihologija, Temeljne medicinske znanosti