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Pregled bibliografske jedinice broj: 1131461

Moderating Effects of BDNF Genetic Variants and Smoking on Cognition in PTSD Veterans


Nedić Erjavec, Gordana; Nikolac Perković, Matea; Tudor, Lucija; Uzun, Suzana; Kovačić Petrović, Zrnka; Konjevod, Marcela; Sagud, Marina; Kozumplik, Oliver; Švob Štrac, Dubravka; Peraica, Tina et al.
Moderating Effects of BDNF Genetic Variants and Smoking on Cognition in PTSD Veterans // Biomolecules, 11 (2021), 5; 641, 20 doi:10.3390/biom11050641 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1131461 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Moderating Effects of BDNF Genetic Variants and Smoking on Cognition in PTSD Veterans

Autori
Nedić Erjavec, Gordana ; Nikolac Perković, Matea ; Tudor, Lucija ; Uzun, Suzana ; Kovačić Petrović, Zrnka ; Konjevod, Marcela ; Sagud, Marina ; Kozumplik, Oliver ; Švob Štrac, Dubravka ; Peraica, Tina ; Mimica, Ninoslav ; Havelka Mestrović, Ana ; Žilić, Denis ; Pivac, Nela

Izvornik
Biomolecules (2218-273X) 11 (2021), 5; 641, 20

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
BDNF rs56164415 ; BDNF rs6265 ; PTSD ; cognition ; smoking ; war veterans

Sažetak
Posttraumatic stress disorder (PTSD) is frequently associated with cognitive disturbances and high prevalence of smoking. This study evaluated cognition in war veterans with PTSD and control subjects, controlled for the effect of smoking and brain derived neurotrophic factor (BDNF) rs6265 and rs56164415 genotypes/alleles. Study included 643 male war veterans with combat related PTSD and 120 healthy controls. Genotyping was done by real time PCR. Cognitive disturbances were evaluated using the Positive and Negative Syndrome Scale (PANSS) cognition subscale and the Rey-Osterrieth Complex Figure (ROCF) test scores. Diagnosis (p < 0.001), BDNF rs56164415 (p = 0.011) and smoking (p = 0.028) were significant predictors of the cognitive decline in subjects with PTSD. BDNF rs56164415 T alleles were more frequently found in subjects with PTSD, smokers and non-smokers, with impaired cognition, i.e., with the higher PANSS cognition subscale scores and with the lower ROCF immediate recall test scores. Presence of one or two BDNF rs56164415 T alleles was related to cognitive decline in PTSD. The T allele carriers with PTSD had advanced cognitive deterioration in smokers and nonsmokers with PTSD, and worse short-term visual memory function. Our findings emphasize the role of the BDNF rs56164415 T allele and smoking in cognitive dysfunction in war veterans with PTSD.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove:
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb,
Klinika za psihijatriju Vrapče,
Klinička bolnica "Dubrava",
Klinički bolnički centar Zagreb

Poveznice na cjeloviti tekst rada:

doi www.mdpi.com doi.org fulir.irb.hr

Citiraj ovu publikaciju:

Nedić Erjavec, Gordana; Nikolac Perković, Matea; Tudor, Lucija; Uzun, Suzana; Kovačić Petrović, Zrnka; Konjevod, Marcela; Sagud, Marina; Kozumplik, Oliver; Švob Štrac, Dubravka; Peraica, Tina et al.
Moderating Effects of BDNF Genetic Variants and Smoking on Cognition in PTSD Veterans // Biomolecules, 11 (2021), 5; 641, 20 doi:10.3390/biom11050641 (međunarodna recenzija, članak, znanstveni)
Nedić Erjavec, G., Nikolac Perković, M., Tudor, L., Uzun, S., Kovačić Petrović, Z., Konjevod, M., Sagud, M., Kozumplik, O., Švob Štrac, D. & Peraica, T. (2021) Moderating Effects of BDNF Genetic Variants and Smoking on Cognition in PTSD Veterans. Biomolecules, 11 (5), 641, 20 doi:10.3390/biom11050641.
@article{article, author = {Nedi\'{c} Erjavec, Gordana and Nikolac Perkovi\'{c}, Matea and Tudor, Lucija and Uzun, Suzana and Kova\v{c}i\'{c} Petrovi\'{c}, Zrnka and Konjevod, Marcela and Sagud, Marina and Kozumplik, Oliver and \v{S}vob \v{S}trac, Dubravka and Peraica, Tina and Mimica, Ninoslav and Havelka Mestrovi\'{c}, Ana and \v{Z}ili\'{c}, Denis and Pivac, Nela}, year = {2021}, pages = {20}, DOI = {10.3390/biom11050641}, chapter = {641}, keywords = {BDNF rs56164415, BDNF rs6265, PTSD, cognition, smoking, war veterans}, journal = {Biomolecules}, doi = {10.3390/biom11050641}, volume = {11}, number = {5}, issn = {2218-273X}, title = {Moderating Effects of BDNF Genetic Variants and Smoking on Cognition in PTSD Veterans}, keyword = {BDNF rs56164415, BDNF rs6265, PTSD, cognition, smoking, war veterans}, chapternumber = {641} }
@article{article, author = {Nedi\'{c} Erjavec, Gordana and Nikolac Perkovi\'{c}, Matea and Tudor, Lucija and Uzun, Suzana and Kova\v{c}i\'{c} Petrovi\'{c}, Zrnka and Konjevod, Marcela and Sagud, Marina and Kozumplik, Oliver and \v{S}vob \v{S}trac, Dubravka and Peraica, Tina and Mimica, Ninoslav and Havelka Mestrovi\'{c}, Ana and \v{Z}ili\'{c}, Denis and Pivac, Nela}, year = {2021}, pages = {20}, DOI = {10.3390/biom11050641}, chapter = {641}, keywords = {BDNF rs56164415, BDNF rs6265, PTSD, cognition, smoking, war veterans}, journal = {Biomolecules}, doi = {10.3390/biom11050641}, volume = {11}, number = {5}, issn = {2218-273X}, title = {Moderating Effects of BDNF Genetic Variants and Smoking on Cognition in PTSD Veterans}, keyword = {BDNF rs56164415, BDNF rs6265, PTSD, cognition, smoking, war veterans}, chapternumber = {641} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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