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The onset of systemic oxidative stress associated with the accumulation of lipid peroxidation product acrolein in the skin of patients with small-vessel vasculitis (CROSBI ID 295402)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Sredoja Tišma, Vesna ; Bulimbašić, Stela ; Galešić Ljubanović, Danica ; Galešić, Krešimir ; Morović- Vergles, Jadranka ; Mitrović, Joško ; Uchida, Koji ; Tatzber, Franz ; Žarković, Neven ; Jaganjac, Morana The onset of systemic oxidative stress associated with the accumulation of lipid peroxidation product acrolein in the skin of patients with small-vessel vasculitis // Molecules, 26 (2021), 8; 2344, 13. doi: 10.3390/molecules26082344

Podaci o odgovornosti

Sredoja Tišma, Vesna ; Bulimbašić, Stela ; Galešić Ljubanović, Danica ; Galešić, Krešimir ; Morović- Vergles, Jadranka ; Mitrović, Joško ; Uchida, Koji ; Tatzber, Franz ; Žarković, Neven ; Jaganjac, Morana

engleski

The onset of systemic oxidative stress associated with the accumulation of lipid peroxidation product acrolein in the skin of patients with small-vessel vasculitis

Small-vessel vasculitis (SVV) is the inflammation of the vessel wall that can result in hemorrhage and/or ischemia. Among the histological findings in SVV are increased infiltrating neutrophils, which, due to their oxidative burst and myeloperoxidase activity, release excessive reactive oxygen species, triggering a chain reaction of lipid peroxidation and yielding reactive aldehydes such as acrolein. The implication of oxidative stress in the pathogenesis of SVV was studied, focusing on acrolein immunohistochemistry in the affected skin vessels and systemic stress response. Samples from SVV patients and healthy subjects were collected and analyzed for total serum peroxides, total antioxidant capacity, inflammatory and immunological parameters, as well as for the presence of acrolein–protein adducts in the skin tissue specimens. The obtained data showed that systemic redox homeostasis and iron metabolism are altered in SVV patients. Possible biomarkers in the evaluation of oxidative status, disease activity and prevalence were indicated. Furthermore, a strong correlation between the accumulation of acrolein–protein adducts in the skin and the progression of the disease was revealed. Thus, the results of this study demonstrate that SVV is not only associated with systemic oxidative stress but also with tissue- specific oxidative stress that promotes acrolein formation and protein modification correlating with the severity of cutaneous vasculitis.

vasculitis ; oxidative stress ; lipid peroxidation ; acrolein

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

26 (8)

2021.

2344

13

objavljeno

1420-3049

10.3390/molecules26082344

Povezanost rada

Temeljne medicinske znanosti

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