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Pregled bibliografske jedinice broj: 1131085

The Onset of Systemic Oxidative Stress Associated with the Accumulation of Lipid Peroxidation Product Acrolein in the Skin of Patients with Small-Vessel Vasculitis


Sredoja Tišma, Vesna; Bulimbasić, Stela; Galešić Ljubanović, Danica; Galešić, Kresimir; Morović-Vergles, Jadranka; Mitrović, Joško; Uchida, Koji; Tatzber, Franz; Žarković, Neven; Jaganjac, Morana
The Onset of Systemic Oxidative Stress Associated with the Accumulation of Lipid Peroxidation Product Acrolein in the Skin of Patients with Small-Vessel Vasculitis // Molecules, 26 (2021), 8; 2344, 13 doi:10.3390/molecules26082344 (međunarodna recenzija, članak, znanstveni)


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Naslov
The Onset of Systemic Oxidative Stress Associated with the Accumulation of Lipid Peroxidation Product Acrolein in the Skin of Patients with Small-Vessel Vasculitis

Autori
Sredoja Tišma, Vesna ; Bulimbasić, Stela ; Galešić Ljubanović, Danica ; Galešić, Kresimir ; Morović-Vergles, Jadranka ; Mitrović, Joško ; Uchida, Koji ; Tatzber, Franz ; Žarković, Neven ; Jaganjac, Morana

Izvornik
Molecules (1420-3049) 26 (2021), 8; 2344, 13

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
vasculitis ; oxidative stress ; lipid peroxidation ; acrolein

Sažetak
Small-vessel vasculitis (SVV) is the inflammation of the vessel wall that can result in hemorrhage and/or ischemia. Among the histological findings in SVV are increased infiltrating neutrophils, which, due to their oxidative burst and myeloperoxidase activity, release excessive reactive oxygen species, triggering a chain reaction of lipid peroxidation and yielding reactive aldehydes such as acrolein. The implication of oxidative stress in the pathogenesis of SVV was studied, focusing on acrolein immunohistochemistry in the affected skin vessels and systemic stress response. Samples from SVV patients and healthy subjects were collected and analyzed for total serum peroxides, total antioxidant capacity, inflammatory and immunological parameters, as well as for the presence of acrolein–protein adducts in the skin tissue specimens. The obtained data showed that systemic redox homeostasis and iron metabolism are altered in SVV patients. Possible biomarkers in the evaluation of oxidative status, disease activity and prevalence were indicated. Furthermore, a strong correlation between the accumulation of acrolein–protein adducts in the skin and the progression of the disease was revealed. Thus, the results of this study demonstrate that SVV is not only associated with systemic oxidative stress but also with tissue-specific oxidative stress that promotes acrolein formation and protein modification correlating with the severity of cutaneous vasculitis.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Ustanove:
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb,
Klinička bolnica "Dubrava",
Klinički bolnički centar Zagreb

Poveznice na cjeloviti tekst rada:

doi www.mdpi.com doi.org fulir.irb.hr

Citiraj ovu publikaciju:

Sredoja Tišma, Vesna; Bulimbasić, Stela; Galešić Ljubanović, Danica; Galešić, Kresimir; Morović-Vergles, Jadranka; Mitrović, Joško; Uchida, Koji; Tatzber, Franz; Žarković, Neven; Jaganjac, Morana
The Onset of Systemic Oxidative Stress Associated with the Accumulation of Lipid Peroxidation Product Acrolein in the Skin of Patients with Small-Vessel Vasculitis // Molecules, 26 (2021), 8; 2344, 13 doi:10.3390/molecules26082344 (međunarodna recenzija, članak, znanstveni)
Sredoja Tišma, V., Bulimbasić, S., Galešić Ljubanović, D., Galešić, K., Morović-Vergles, J., Mitrović, J., Uchida, K., Tatzber, F., Žarković, N. & Jaganjac, M. (2021) The Onset of Systemic Oxidative Stress Associated with the Accumulation of Lipid Peroxidation Product Acrolein in the Skin of Patients with Small-Vessel Vasculitis. Molecules, 26 (8), 2344, 13 doi:10.3390/molecules26082344.
@article{article, author = {Sredoja Ti\v{s}ma, Vesna and Bulimbasi\'{c}, Stela and Gale\v{s}i\'{c} Ljubanovi\'{c}, Danica and Gale\v{s}i\'{c}, Kresimir and Morovi\'{c}-Vergles, Jadranka and Mitrovi\'{c}, Jo\v{s}ko and Uchida, Koji and Tatzber, Franz and \v{Z}arkovi\'{c}, Neven and Jaganjac, Morana}, year = {2021}, pages = {13}, DOI = {10.3390/molecules26082344}, chapter = {2344}, keywords = {vasculitis, oxidative stress, lipid peroxidation, acrolein}, journal = {Molecules}, doi = {10.3390/molecules26082344}, volume = {26}, number = {8}, issn = {1420-3049}, title = {The Onset of Systemic Oxidative Stress Associated with the Accumulation of Lipid Peroxidation Product Acrolein in the Skin of Patients with Small-Vessel Vasculitis}, keyword = {vasculitis, oxidative stress, lipid peroxidation, acrolein}, chapternumber = {2344} }
@article{article, author = {Sredoja Ti\v{s}ma, Vesna and Bulimbasi\'{c}, Stela and Gale\v{s}i\'{c} Ljubanovi\'{c}, Danica and Gale\v{s}i\'{c}, Kresimir and Morovi\'{c}-Vergles, Jadranka and Mitrovi\'{c}, Jo\v{s}ko and Uchida, Koji and Tatzber, Franz and \v{Z}arkovi\'{c}, Neven and Jaganjac, Morana}, year = {2021}, pages = {13}, DOI = {10.3390/molecules26082344}, chapter = {2344}, keywords = {vasculitis, oxidative stress, lipid peroxidation, acrolein}, journal = {Molecules}, doi = {10.3390/molecules26082344}, volume = {26}, number = {8}, issn = {1420-3049}, title = {The Onset of Systemic Oxidative Stress Associated with the Accumulation of Lipid Peroxidation Product Acrolein in the Skin of Patients with Small-Vessel Vasculitis}, keyword = {vasculitis, oxidative stress, lipid peroxidation, acrolein}, chapternumber = {2344} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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