engleski

Neuroscience of developing axonal strata in the human fetal brain

Sagittal strata represent bilateral, parasagittally oriented, white matter fiber system running from the frontal towards the occipital pole. They appear during the early fetal life, form trajectories of commissural, projection, and associative axonal pathways, and participate in the transformation of transient fetal zones/white matter segments into the fetal white matter during the late fetal period. Early sagittal strata (10 PCW) appear in the intermediate zone containing thalamic projection and fibers from basal forebrain. During the mid-gestation, they show complex histogenetic “interaction” with adjacent fetal (mainly proliferative) zones, forming multilaminar architecture of fibrillar and cellular layers. Approaching the late fetal period, associative pathways develop at the border of sagittal strata and deep portion of the subplate zone, emphasizing their potential clinical meaning, especially considering their prominent display on magnetic resonance imaging.

brain development ; fetal white matter ; sagittal strata ; transient fetal zones ; white matter segments

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