Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 1130911

Trace elements concentration in adipose tissue and the risk of incident type 2 diabetes in a prospective adult cohort


Rodríguez-Pérez, Celia; Gómez Peña, Celia; Pérez-Carrascosa, Francisco M.; Vrhovnik, Petra; Echeverría, Ruth; Salcedo-Bellido, Inmaculada; Mustieles, Vicente; Fiket, Željka; Arrebola, Juan Pedro
Trace elements concentration in adipose tissue and the risk of incident type 2 diabetes in a prospective adult cohort // Environmental pollution (2021) doi:10.1016/j.envpol.2021.117496 (znanstveni, prihvaćen)


CROSBI ID: 1130911 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Trace elements concentration in adipose tissue and the risk of incident type 2 diabetes in a prospective adult cohort

Autori
Rodríguez-Pérez, Celia ; Gómez Peña, Celia ; Pérez-Carrascosa, Francisco M. ; Vrhovnik, Petra ; Echeverría, Ruth ; Salcedo-Bellido, Inmaculada ; Mustieles, Vicente ; Fiket, Željka ; Arrebola, Juan Pedro

Vrsta, podvrsta
Radovi u časopisima, znanstveni

Izvornik
Environmental pollution (2021)

Status rada
Prihvaćen

Ključne riječi
Adipose tissue ; Chromium ; Diabetes ; Iron, Copper ; Trace elements

Sažetak
The aim of this work is to study the associations of adipose tissue TE concentrations with type 2 diabetes (T2DM) incidence over a 16-year follow-up period in an adult cohort from Southern Spain. Clinical information, including 16-year T2DM incidence, was gathered from hospital records. Chemical analyses of Cr, V, Zn, Fe, Cu and Se in adipose tissue were performed using inductively coupled plasma mass spectrometry. Multivariable Cox- regression models were used. Adipose tissue concentrations of individual TEs showed that Fe (HR = 1.59, 95% CI: 0.99 to 2.56, p = 0.057), Cr (HR = 1.58, 95% CI: 1.07–2.33, p = 0.022) and Cu (HR = 1.61, 95% CI: 1.01–2.58, p = 0.046) were positively associated with T2DM incidence. The Cr-association was maintained in multi-TEs analysis (HR = 1.68, 95% CI: 1.02– 2.76, p = 0.041). Furthermore, adipose tissue V (β = 0.283, p = 0.004) and Zn (β = 0.217, p = 0.028) concentrations were positively associated with β-pancreatic cell function (HOMA-β), while Se showed an inverse association (β = −0.049, p = 0.027). Although further research is warranted on the potential mechanisms of action, our results suggest that adipose tissue concentrations of certain trace elements (particularly Fe, Cr and Cu) are associated with the risk of incident T2DM, while V and Zn might have a protective effect. These biomarkers might complement prediction algorithms and contribute to identify patients with an increased risk of T2DM.

Izvorni jezik
Engleski

Znanstvena područja
Interdisciplinarne prirodne znanosti



POVEZANOST RADA


Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Željka Fiket (autor)

Citiraj ovu publikaciju

Rodríguez-Pérez, Celia; Gómez Peña, Celia; Pérez-Carrascosa, Francisco M.; Vrhovnik, Petra; Echeverría, Ruth; Salcedo-Bellido, Inmaculada; Mustieles, Vicente; Fiket, Željka; Arrebola, Juan Pedro
Trace elements concentration in adipose tissue and the risk of incident type 2 diabetes in a prospective adult cohort // Environmental pollution (2021) doi:10.1016/j.envpol.2021.117496 (znanstveni, prihvaćen)
Rodríguez-Pérez, C., Gómez Peña, C., Pérez-Carrascosa, F., Vrhovnik, P., Echeverría, R., Salcedo-Bellido, I., Mustieles, V., Fiket, Ž. & Arrebola, J. (2021) Trace elements concentration in adipose tissue and the risk of incident type 2 diabetes in a prospective adult cohort. Prihvaćen za objavljivanje u Environmental pollution. [Preprint] doi:10.1016/j.envpol.2021.117496.
@unknown{unknown, year = {2021}, DOI = {10.1016/j.envpol.2021.117496}, keywords = {Adipose tissue, Chromium, Diabetes, Iron, Copper, Trace elements}, journal = {Environmental pollution}, doi = {10.1016/j.envpol.2021.117496}, title = {Trace elements concentration in adipose tissue and the risk of incident type 2 diabetes in a prospective adult cohort}, keyword = {Adipose tissue, Chromium, Diabetes, Iron, Copper, Trace elements} }
@unknown{unknown, year = {2021}, DOI = {10.1016/j.envpol.2021.117496}, keywords = {Adipose tissue, Chromium, Diabetes, Iron, Copper, Trace elements}, journal = {Environmental pollution}, doi = {10.1016/j.envpol.2021.117496}, title = {Trace elements concentration in adipose tissue and the risk of incident type 2 diabetes in a prospective adult cohort}, keyword = {Adipose tissue, Chromium, Diabetes, Iron, Copper, Trace elements} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati





    Contrast
    Increase Font
    Decrease Font
    Dyslexic Font