Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 1128770

Topical NAVS naphthalan for the treatment of oral lichen planus and recurrent aphthous stomatitis: A double blind, randomized, parallel group study


Andabak Rogulj, Ana; Alajbeg Žilić, Iva; Brailo, Vlaho; Škrinjar, Ivana; Žužul, Ivona; Vučićević Boras, Vanja; Alajbeg, Ivan
Topical NAVS naphthalan for the treatment of oral lichen planus and recurrent aphthous stomatitis: A double blind, randomized, parallel group study // PLoS One, 16 (2021), 4; 1-14 doi:10.1371/journal.pone.0249862 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1128770 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Topical NAVS naphthalan for the treatment of oral lichen planus and recurrent aphthous stomatitis: A double blind, randomized, parallel group study

Autori
Andabak Rogulj, Ana ; Alajbeg Žilić, Iva ; Brailo, Vlaho ; Škrinjar, Ivana ; Žužul, Ivona ; Vučićević Boras, Vanja ; Alajbeg, Ivan

Izvornik
PLoS One (1932-6203) 16 (2021), 4; 1-14

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
NAVS naphthalan ; oral lichen planus ; recurrent aphthous stomatitis

Sažetak
Aim To evaluate the effectiveness of non-aromatic very rich in steranes (NAVS) naphthalan in the treatment of oral lichen planus (OLP) and recurrent aphthous stomatitis (RAS). Null hypothesis was that there would be no difference between NAVS and topical steroids in the treatment of OLP and RAS. Methods The study consisted of two sub-trials conducted as randomized, double-blind controlled studies: first included OLP patients and second patients with RAS. Patients received either NAVS or 0.05% betamethasone dipropionate. Primary outcomes were activity score (OLP patients), No of lesions and lesion diameter (RAS patients) and pain intensity (VAS) while secondary outcome included the impact of the disease on quality of life assessed by Oral health impact profile (OHIP 14). Results No significant differences in terms of OLP clinical signs (p = 0.84, η2 = 0.001) and responses on the OHIP-14 (p = 0.81, η2 = 0.002) or on VAS (p = 0.14, η2 = 0.079) between NAVS and betamethasone groups were observed. In RAS patients, no significant differences between the groups in terms of lesion number (at days 3 and 5, p = 0.33 and p = 0.98, respectively), lesion diameter (days 3 and 5, p = 0.24 and p = 0.84, respectively) were observed. However, in NAVS group a significant reduction of lesions diameter was observed on the 3rd day, while in betamethasone group a significant reduction in lesions diameter was evident only after the 5th day. No significant differences in VAS (p > 0.05) and the OHIP-14 (p > 0.05) between groups were found. Conclusion No evidence of differences between the two compared interventions was found.

Izvorni jezik
Engleski

Znanstvena područja
Dentalna medicina



POVEZANOST RADA


Projekti:
IP-2019-04-6211 - Povezanost genskih polimorfizama s temporomandibularnim poremećajima (GenPolTMD) (Alajbeg, Iva, HRZZ - 2019-04) ( POIROT)

Ustanove:
Stomatološki fakultet, Zagreb

Poveznice na cjeloviti tekst rada:

Pristup cjelovitom tekstu rada doi journals.plos.org

Citiraj ovu publikaciju:

Andabak Rogulj, Ana; Alajbeg Žilić, Iva; Brailo, Vlaho; Škrinjar, Ivana; Žužul, Ivona; Vučićević Boras, Vanja; Alajbeg, Ivan
Topical NAVS naphthalan for the treatment of oral lichen planus and recurrent aphthous stomatitis: A double blind, randomized, parallel group study // PLoS One, 16 (2021), 4; 1-14 doi:10.1371/journal.pone.0249862 (međunarodna recenzija, članak, znanstveni)
Andabak Rogulj, A., Alajbeg Žilić, I., Brailo, V., Škrinjar, I., Žužul, I., Vučićević Boras, V. & Alajbeg, I. (2021) Topical NAVS naphthalan for the treatment of oral lichen planus and recurrent aphthous stomatitis: A double blind, randomized, parallel group study. PLoS One, 16 (4), 1-14 doi:10.1371/journal.pone.0249862.
@article{article, author = {Andabak Rogulj, Ana and Alajbeg \v{Z}ili\'{c}, Iva and Brailo, Vlaho and \v{S}krinjar, Ivana and \v{Z}u\v{z}ul, Ivona and Vu\v{c}i\'{c}evi\'{c} Boras, Vanja and Alajbeg, Ivan}, year = {2021}, pages = {1-14}, DOI = {10.1371/journal.pone.0249862}, keywords = {NAVS naphthalan, oral lichen planus, recurrent aphthous stomatitis}, journal = {PLoS One}, doi = {10.1371/journal.pone.0249862}, volume = {16}, number = {4}, issn = {1932-6203}, title = {Topical NAVS naphthalan for the treatment of oral lichen planus and recurrent aphthous stomatitis: A double blind, randomized, parallel group study}, keyword = {NAVS naphthalan, oral lichen planus, recurrent aphthous stomatitis} }
@article{article, author = {Andabak Rogulj, Ana and Alajbeg \v{Z}ili\'{c}, Iva and Brailo, Vlaho and \v{S}krinjar, Ivana and \v{Z}u\v{z}ul, Ivona and Vu\v{c}i\'{c}evi\'{c} Boras, Vanja and Alajbeg, Ivan}, year = {2021}, pages = {1-14}, DOI = {10.1371/journal.pone.0249862}, keywords = {NAVS naphthalan, oral lichen planus, recurrent aphthous stomatitis}, journal = {PLoS One}, doi = {10.1371/journal.pone.0249862}, volume = {16}, number = {4}, issn = {1932-6203}, title = {Topical NAVS naphthalan for the treatment of oral lichen planus and recurrent aphthous stomatitis: A double blind, randomized, parallel group study}, keyword = {NAVS naphthalan, oral lichen planus, recurrent aphthous stomatitis} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati:





    Contrast
    Increase Font
    Decrease Font
    Dyslexic Font