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Pregled bibliografske jedinice broj: 1127847

PD-L1 PROTEIN EXPRESSION IN NSCLC NON-CELL BLOCK CYTOLOGY IN CORRELATION WITH PATIENTS CLINICAL DATA


Šimić, Vesna; Vrabec Branica, Božica; Harabajsa, Suzana; Jakopović, Marko; Smojver-Ježek, Silvana
PD-L1 PROTEIN EXPRESSION IN NSCLC NON-CELL BLOCK CYTOLOGY IN CORRELATION WITH PATIENTS CLINICAL DATA // 6. Croatian congress of clinical cytology, 3rd Croatian symposium of analytical cytology, 4th Croatian symposium of cytotechnology with international participation
Hrvatska, 2021. str. 77-77 (predavanje, podatak o recenziji nije dostupan, sažetak, stručni)


CROSBI ID: 1127847 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
PD-L1 PROTEIN EXPRESSION IN NSCLC NON-CELL BLOCK CYTOLOGY IN CORRELATION WITH PATIENTS CLINICAL DATA

Autori
Šimić, Vesna ; Vrabec Branica, Božica ; Harabajsa, Suzana ; Jakopović, Marko ; Smojver-Ježek, Silvana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Skup
6. Croatian congress of clinical cytology, 3rd Croatian symposium of analytical cytology, 4th Croatian symposium of cytotechnology with international participation

Mjesto i datum
Hrvatska, 13.05.2021. - 15.05.2021

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Podatak o recenziji nije dostupan

Ključne riječi
PD-L1, immunocytochemistry, NSCLC, non cell-block cytology

Sažetak
Aim: To compare the PD-L1 protein expression in NSCLC on various non-cell block cytology and patients clinical data. Materials and methods: Archive records of the clinical data and results of PD-L1 expression in patients with NSCLC over a period of one year. Materials were collected during bronchoscopy (bronchial washing/brushing and transbronchial fine needle aspirations), FNA of peripheral lymph nodes, skin nodules, transthoracic FNA/biopsy and pleural effusion. All materials were prepared as air dried non-cell block cytology slides and stained with Anti-PD-L1, Clone 22C3, Dako by Autostainer. PD-L1 protein expression was routinely examined and scored using Tumor Proportion Score(TPS) by two cytologists. Result: We have compared results of 341 patients out of 393 that underwent PD-L1 scoring. There were 216 smears of bronchoscopic material and 125 of various non bronchoscopic samples (FNA, PE, etc). PD-L1 was negative in total of 179/341 (52, 5%) samples. PD-L1 was positive in total of 162/341 (47, 5%) samples. Among PD-L1 positive, 105/162 were materials from bronchoscopy and 57/162 were obtained with others methods. PDL1 scored positive ≥ 50% in 72 samples, of which 45/72 (62, 5%) were bronchoscopic materials and 27/72(37, 5%) other materials. Comparison in PD-L1 expression between two groups of materials showed no statistical significant difference (x²test, df 1, p=.591). Comparison between two groups of PD-L1 positive ≥50% showed no statistical significant difference (x²test, df 1, p=.581). Among 341 included patients there were 210/341 (61, 6%) male and 131/341 (38, 4%) female. Most of the patients were in stage IV of disease 219/341 (64.2%) and older than 61 year 265/341 (77, 7%). The patients that were PD-L1 positive were in stage IV of disease in 95/162 (58, 6%) cases and most of them smoke 74/162(45, 7%) or were former smokers 59/162(36, 4%).Comparison of PD-L1 expression between gender (x²test, df 2, p=.55762.) smoking history(x²test, df 6, p=.59954.), stage of disease (x²test, df 8 p=.469207), and age (x²test, df 2, p=.834388.) show no statistical significant difference among groups. Out of 162 patients that were PD-L1 positive, 69 (42, 6%) received immunotherapy treatment. Conclusion:In our study there were no statistical significant differences in PD-L1 protein expression between different groups regarding gender, age, smoking status, stage of disease and material collecting method.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove:
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb


Citiraj ovu publikaciju:

Šimić, Vesna; Vrabec Branica, Božica; Harabajsa, Suzana; Jakopović, Marko; Smojver-Ježek, Silvana
PD-L1 PROTEIN EXPRESSION IN NSCLC NON-CELL BLOCK CYTOLOGY IN CORRELATION WITH PATIENTS CLINICAL DATA // 6. Croatian congress of clinical cytology, 3rd Croatian symposium of analytical cytology, 4th Croatian symposium of cytotechnology with international participation
Hrvatska, 2021. str. 77-77 (predavanje, podatak o recenziji nije dostupan, sažetak, stručni)
Šimić, V., Vrabec Branica, B., Harabajsa, S., Jakopović, M. & Smojver-Ježek, S. (2021) PD-L1 PROTEIN EXPRESSION IN NSCLC NON-CELL BLOCK CYTOLOGY IN CORRELATION WITH PATIENTS CLINICAL DATA. U: 6. Croatian congress of clinical cytology, 3rd Croatian symposium of analytical cytology, 4th Croatian symposium of cytotechnology with international participation.
@article{article, author = {\v{S}imi\'{c}, Vesna and Vrabec Branica, Bo\v{z}ica and Harabajsa, Suzana and Jakopovi\'{c}, Marko and Smojver-Je\v{z}ek, Silvana}, year = {2021}, pages = {77-77}, keywords = {PD-L1, immunocytochemistry, NSCLC, non cell-block cytology}, title = {PD-L1 PROTEIN EXPRESSION IN NSCLC NON-CELL BLOCK CYTOLOGY IN CORRELATION WITH PATIENTS CLINICAL DATA}, keyword = {PD-L1, immunocytochemistry, NSCLC, non cell-block cytology}, publisherplace = {Hrvatska} }
@article{article, author = {\v{S}imi\'{c}, Vesna and Vrabec Branica, Bo\v{z}ica and Harabajsa, Suzana and Jakopovi\'{c}, Marko and Smojver-Je\v{z}ek, Silvana}, year = {2021}, pages = {77-77}, keywords = {PD-L1, immunocytochemistry, NSCLC, non cell-block cytology}, title = {PD-L1 PROTEIN EXPRESSION IN NSCLC NON-CELL BLOCK CYTOLOGY IN CORRELATION WITH PATIENTS CLINICAL DATA}, keyword = {PD-L1, immunocytochemistry, NSCLC, non cell-block cytology}, publisherplace = {Hrvatska} }




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