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Pregled bibliografske jedinice broj: 1127669

Metabolic disturbances in rat sublines with constitutionally altered serotonin homeostasis


Kesić, Maja; Baković, Petra; Stojković, Ranko; Štefulj, Jasminka; Čičin-Šain, Lipa
Metabolic disturbances in rat sublines with constitutionally altered serotonin homeostasis // International journal of molecular sciences, 22 (2021), 10; 5400, 20 doi:10.3390/ijms22105400 (međunarodna recenzija, članak, znanstveni)


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Naslov
Metabolic disturbances in rat sublines with constitutionally altered serotonin homeostasis

Autori
Kesić, Maja ; Baković, Petra ; Stojković, Ranko ; Štefulj, Jasminka ; Čičin-Šain, Lipa

Izvornik
International journal of molecular sciences (1422-0067) 22 (2021), 10; 5400, 20

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
serotonin ; obesity ; metabolism ; genetic rat model ; adipose tissue

Sažetak
Central and peripheral serotonin (5HT) have opposing functions in the regulation of energy homeostasis. Both increasing 5HT signaling in the brain and decreasing 5HT signaling in the periphery have been proposed as potential treatments for obesity. This study investigates the relationship between constitutionally high or low 5HT activity and systemic net energy balance. Two sublines of rats with high and low whole-body 5HT tone, obtained by selective breeding for platelet 5HT parameters, were examined for fat accumulation in different white adipose tissue (WAT) depots, glucose/insulin tolerance, blood metabolic parameters, and expression of various metabolic genes. High-5HT animals, unlike their low-5HT counterparts, developed widespread intra- abdominal obesity associated with glucose and insulin intolerance, which worsened with age. They also had elevated blood glucose and lipid parameters but showed no significant changes in circulating leptin, resistin, and adipsin levels. Surprisingly, adiponectin levels were increased in plasma but reduced in the WAT of high-5HT rats. A limited number of metabolic genes belonging to different functional classes showed differential expression in WAT of high- 5HT compared to low-5HT rats. Overall, a constitutive increase in 5HT tone is associated with a positive energy balance acting through subtle dysregulation of a broad spectrum of metabolic pathways.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA


Projekti:
IP-2014-09-7827 - Serotonergična modulacija pretilosti: međuovisnost regulatornih molekula i puteva (SERT-OB) (Čičin-Šain, Lipa, HRZZ - 2014-09) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Poveznice na cjeloviti tekst rada:

doi www.mdpi.com doi.org fulir.irb.hr

Citiraj ovu publikaciju:

Kesić, Maja; Baković, Petra; Stojković, Ranko; Štefulj, Jasminka; Čičin-Šain, Lipa
Metabolic disturbances in rat sublines with constitutionally altered serotonin homeostasis // International journal of molecular sciences, 22 (2021), 10; 5400, 20 doi:10.3390/ijms22105400 (međunarodna recenzija, članak, znanstveni)
Kesić, M., Baković, P., Stojković, R., Štefulj, J. & Čičin-Šain, L. (2021) Metabolic disturbances in rat sublines with constitutionally altered serotonin homeostasis. International journal of molecular sciences, 22 (10), 5400, 20 doi:10.3390/ijms22105400.
@article{article, author = {Kesi\'{c}, Maja and Bakovi\'{c}, Petra and Stojkovi\'{c}, Ranko and \v{S}tefulj, Jasminka and \v{C}i\v{c}in-\v{S}ain, Lipa}, year = {2021}, pages = {20}, DOI = {10.3390/ijms22105400}, chapter = {5400}, keywords = {serotonin, obesity, metabolism, genetic rat model, adipose tissue}, journal = {International journal of molecular sciences}, doi = {10.3390/ijms22105400}, volume = {22}, number = {10}, issn = {1422-0067}, title = {Metabolic disturbances in rat sublines with constitutionally altered serotonin homeostasis}, keyword = {serotonin, obesity, metabolism, genetic rat model, adipose tissue}, chapternumber = {5400} }
@article{article, author = {Kesi\'{c}, Maja and Bakovi\'{c}, Petra and Stojkovi\'{c}, Ranko and \v{S}tefulj, Jasminka and \v{C}i\v{c}in-\v{S}ain, Lipa}, year = {2021}, pages = {20}, DOI = {10.3390/ijms22105400}, chapter = {5400}, keywords = {serotonin, obesity, metabolism, genetic rat model, adipose tissue}, journal = {International journal of molecular sciences}, doi = {10.3390/ijms22105400}, volume = {22}, number = {10}, issn = {1422-0067}, title = {Metabolic disturbances in rat sublines with constitutionally altered serotonin homeostasis}, keyword = {serotonin, obesity, metabolism, genetic rat model, adipose tissue}, chapternumber = {5400} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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