Structural, antioxidant, antiproliferative, and in-silico study of pyridine-based hydrazonyl- selenazoles and their sulphur isosteres (CROSBI ID 294690)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Araškov, Jovana ; Nikolić, Milan ; Armaković, Stevan ; Rodić, Marko ; Višnjevac, Aleksandar ; Padron, Jose ; Todorović, Tamara ; Filipović, Nenad
engleski
Structural, antioxidant, antiproliferative, and in-silico study of pyridine-based hydrazonyl- selenazoles and their sulphur isosteres
To evaluate the impact of chalcogen atom type, we performed a comparative study of antioxidant capacity and antiproliferative activity of a focused library of three pyridine-based hydrazonyl-1, 3-selenazoles and their sulfur isosteres in five antioxidant assays and in six human solid tumor cell lines, respectively. Insilico calculations were further used to check pharmacokinetic profiles of investigated compounds such as drug-likeness parameters and interaction with water. Generally, selenium compounds appear to be more potent in comparison to sulfur isosteres in the performed essays.
Hydrazonyl–thiazoles ; Single crystal X-ray analysis ; Antiproliferative activity ; Antioxidant activity ; Drug likeness parameters ; DFT
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Podaci o izdanju
1240
2021.
130512
13
objavljeno
0022-2860
1872-8014
10.1016/j.molstruc.2021.130512
Povezanost rada
Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje), Kemija