engleski

Selected Chapters from the Renin-Angiotensin System

This book aims to provide a selection of chapters reviewing some of the most relevant and interesting physiological and pathophysiological roles of the renin-angiotensin system (RAS) and discussing novel scientific findings. The complex and convoluted RAS has been investigated for many years and, through rigorous scientific research, many important and previously unknown components and functions of the RAS have come to light. These discoveries have been crucial in the understanding of this system and provide a basis for effective modulation of the system as part of therapeutic strategies for a number of widespread disorders. New studies are continuing to elucidate the RAS and the mechanisms associated with its functions. The first chapter, written by Dr. A. Poisner, gives a chronological overview of the many years and decades of important research of the RAS as the scientific community expanded on the importance of this physiological system and established a structured portfolio of knowledge and information about it. The chapter is written with a focus on the personal experiences of Dr Poisner. The next chapter by Dr M. Ciocoiu et al. discusses the genomics, proteomics and therapeutic implications of the RAS. In the following chapter by Dr A. Kibel and coworkers, the significance of the RAS in clinical conditions is presented. The role of RAS in clinically relevant contexts, such as hypertension, heart failure, diabetes mellitus and others can be crucial for both pathogenic reasons and because of therapeutic targeting. The emphasis of the role of the RAS in the treatment of essential hypertension is brought further into focus by Dr G.B. de Oliveira Salvador in his chapter. The intratubular and intracrine RAS in the proximal tubules of the kidney and Its roles in angiotensin II-induced hypertension is discussed by Dr X. C. Li and colleagues. Interesting new scientific results regarding other roles and mechanisms connected to the RAS are susequently discussed in chapters by Dr K. Satue et al. and Dr G. I. Gomez et al. Taken together, the selected chapters in the book discuss relevant scientific knowledge about the RAS and intend to introduce the reader to cutting-edge research of the RAS with an accentuation on the mechanisms on functional/physiological and on the molecular/cellular levels.

renin-angiotensin system, hypertension, heart failure, angiotensin converting enzyme inhibitors, diabetes mellitus

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