Sex Differences in Circadian Clock Genes and Myocardial Infarction Susceptibility (CROSBI ID 294582)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Škrlec, Ivana ; Talapko, Jasminka ; Juzbašić, Martina ; Steiner, Robert
engleski
Sex Differences in Circadian Clock Genes and Myocardial Infarction Susceptibility
The growing body of evidence shows a significant difference in the circadian rhythm of cardiovascular disease based on biological sex. The incidence of cardiovascular disease varies between women and men. Additionally, biological sex is vital for the timely application of therapy—chronotherapy, which benefits both sexes. This study aimed to examine the potential difference of single nucleotide polymorphisms (SNPs) of the circadian rhythm genes ARNTL, CLOCK, CRY2 and PER2 in women and men with myocardial infarction. A cross-sectional study was conducted, including 200 patients with myocardial infarction. Altogether, ten single nucleotide polymorphisms in the ARNTL, CLOCK, CRY2 and PER2 genes were analyzed. The Chi- square test yielded statistically significant differences in CLOCK gene rs11932595 polymorphism in a recessive genotype model between women and men with a p-value of 0.03 and an odds ratio 2.66, and a corresponding 95% confidence interval of 1.07 to 6.66. Other analyzed polymorphisms of the circadian rhythm genes ARNTL, CRY2, and PER2 did not significantly differ between the sexes. According to the study’s current results, the CLOCK gene’s genetic variability might affect myocardial infarction concerning biological sex.
biological sex ; circadian rhythm ; clock genes ; myocardial infarction
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Podaci o izdanju
8 (5)
2021.
1-12
objavljeno
2308-3425
https://doi.org/10.3390/jcdd8050053
Trošak objave rada u otvorenom pristupu
Povezanost rada
Biologija, Kliničke medicinske znanosti, Temeljne medicinske znanosti