Fluorescence spectroscopic study on the interaction of dopamine and L-dopa with different selenium nanoparticles (CROSBI ID 703023)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Kalčec, Nikolina ; Mamić, Ivan ; Peranić, Nikolina ; Vinković Vrček, Ivana
engleski
Fluorescence spectroscopic study on the interaction of dopamine and L-dopa with different selenium nanoparticles
The development of new strategies to treat Parkinson’s disease suffers from many deficiencies. Common therapy that includes external administration of L-dopa to Parkinson’s disease patients is limited due to the lack of targeting ability.[1, 2] As an alternative for conventional therapeutic drugs, selenium nanoparticles (SeNPs) constitute an attractive carrier platform for targeted drug delivery into the brain.[3, 4] In this study, two different SeNPs were designed using polyvinylpyrrolidone (PVP) and polysorbate 20 (Tween) as surface modifiers. Their binding ability for dopamine and L-dopa was evaluated by steady-state fluorescence spectroscopy. The strongest interaction was observed between L-dopa and PVP-SeNPs. Thermodynamic analysis revealed that binding between Tween-SeNPs and L-dopa or dopamine predominantly occurs through van der Waals interactions and hydrogen bonds, while electrostatic interactions govern the binding of L-dopa or dopamine to the PVP-SeNPs. In all cases, interactions were exothermic and spontaneous.
selenium nanoparticles ; L-dopa ; dopamine ; fluorescence spectroscopy
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Podaci o prilogu
109-109.
2021.
objavljeno
Podaci o matičnoj publikaciji
EuroNanoForum 2021 Booklet of Abstracts
Podaci o skupu
EuroNanoForum 2021
poster
05.05.2021-06.05.2021
Braga, Portugal