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Pregled bibliografske jedinice broj: 1126882

Fluorescence spectroscopic study on the interaction of dopamine and L-dopa with different selenium nanoparticles


Kalčec, Nikolina; Mamić, Ivan; Peranić, Nikolina; Vinković Vrček, Ivana
Fluorescence spectroscopic study on the interaction of dopamine and L-dopa with different selenium nanoparticles // EuroNanoForum 2021 Booklet of Abstracts
Braga, Portugal, 2021. str. 109-109 (poster, međunarodna recenzija, sažetak, ostalo)


CROSBI ID: 1126882 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Fluorescence spectroscopic study on the interaction of dopamine and L-dopa with different selenium nanoparticles

Autori
Kalčec, Nikolina ; Mamić, Ivan ; Peranić, Nikolina ; Vinković Vrček, Ivana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
EuroNanoForum 2021 Booklet of Abstracts / - , 2021, 109-109

Skup
EuroNanoForum 2021

Mjesto i datum
Braga, Portugal, 5-6.5.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
selenium nanoparticles ; L-dopa ; dopamine ; fluorescence spectroscopy

Sažetak
The development of new strategies to treat Parkinson’s disease suffers from many deficiencies. Common therapy that includes external administration of L-dopa to Parkinson’s disease patients is limited due to the lack of targeting ability.[1, 2] As an alternative for conventional therapeutic drugs, selenium nanoparticles (SeNPs) constitute an attractive carrier platform for targeted drug delivery into the brain.[3, 4] In this study, two different SeNPs were designed using polyvinylpyrrolidone (PVP) and polysorbate 20 (Tween) as surface modifiers. Their binding ability for dopamine and L-dopa was evaluated by steady-state fluorescence spectroscopy. The strongest interaction was observed between L-dopa and PVP-SeNPs. Thermodynamic analysis revealed that binding between Tween-SeNPs and L-dopa or dopamine predominantly occurs through van der Waals interactions and hydrogen bonds, while electrostatic interactions govern the binding of L-dopa or dopamine to the PVP-SeNPs. In all cases, interactions were exothermic and spontaneous.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Farmacija



POVEZANOST RADA


Projekti:
HRZZ-PZS-2019-02-4323 - Siguran pristup za razvoj nano-sustava za ciljanu isporuku lijekova u mozak (SENDER) (Vinković Vrček, Ivana, HRZZ - 2019-02) ( POIROT)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Institut za medicinska istraživanja i medicinu rada, Zagreb


Citiraj ovu publikaciju:

Kalčec, Nikolina; Mamić, Ivan; Peranić, Nikolina; Vinković Vrček, Ivana
Fluorescence spectroscopic study on the interaction of dopamine and L-dopa with different selenium nanoparticles // EuroNanoForum 2021 Booklet of Abstracts
Braga, Portugal, 2021. str. 109-109 (poster, međunarodna recenzija, sažetak, ostalo)
Kalčec, N., Mamić, I., Peranić, N. & Vinković Vrček, I. (2021) Fluorescence spectroscopic study on the interaction of dopamine and L-dopa with different selenium nanoparticles. U: EuroNanoForum 2021 Booklet of Abstracts.
@article{article, author = {Kal\v{c}ec, Nikolina and Mami\'{c}, Ivan and Perani\'{c}, Nikolina and Vinkovi\'{c} Vr\v{c}ek, Ivana}, year = {2021}, pages = {109-109}, keywords = {selenium nanoparticles, L-dopa, dopamine, fluorescence spectroscopy}, title = {Fluorescence spectroscopic study on the interaction of dopamine and L-dopa with different selenium nanoparticles}, keyword = {selenium nanoparticles, L-dopa, dopamine, fluorescence spectroscopy}, publisherplace = {Braga, Portugal} }
@article{article, author = {Kal\v{c}ec, Nikolina and Mami\'{c}, Ivan and Perani\'{c}, Nikolina and Vinkovi\'{c} Vr\v{c}ek, Ivana}, year = {2021}, pages = {109-109}, keywords = {selenium nanoparticles, L-dopa, dopamine, fluorescence spectroscopy}, title = {Fluorescence spectroscopic study on the interaction of dopamine and L-dopa with different selenium nanoparticles}, keyword = {selenium nanoparticles, L-dopa, dopamine, fluorescence spectroscopy}, publisherplace = {Braga, Portugal} }




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