The genotoxic risk in health care workers occupationally exposed to cytotoxic drugs—A comprehensive evaluation by the SCE assay (CROSBI ID 294495)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Kopjar, Nevenka ; Kašuba, Vilena ; Rozgaj, Ružica ; Želježić, Davor ; Milić, Mirta ; Ramić, Snježana ; Pavlica, Vesna ; Milković Kraus, Sanja
engleski
The genotoxic risk in health care workers occupationally exposed to cytotoxic drugs—A comprehensive evaluation by the SCE assay
Present study aimed at an integral assessment of sister chromatid exchange (SCE) frequencies in the health careworkers occupationally exposed to cytostatics. The results of 500 individual analyses were evaluated. Drug handling practice was investigated in parallel and the results showed that cytostatics are mostly prepared outside hospital pharmacy (98%) and mainly handled by nurses (96%). Mean frequency of SCE was 5.63 ± 2.28, while HFC represented 9.65% of the cells analysed. Both values were higher compared to previously established control values for Croatian population. The duration of exposure, profession, age, gender, smoking habit, medical exposures, and simultaneous exposure to other occupational mutagens significantly contributed to SCE and HFC values. The usefulness both biomarkers in the assessment of cytogenetic damage is confirmed. Since current practice in Croatian hospitals does not include regular monitoring of workplaces, to ensure maximal occupational safety, a surveillance on exposed health care workers, including periodic biomonitoring, is recommended.
Cytotoxic drugs ; occupational exposure ; sister chromatid exchanges ; lymphocytes ; genotoxicity
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Podaci o izdanju
44
2009.
462-479
objavljeno
1093-4529
1532-4117
10.1080/10934520902719845
Povezanost rada
Biologija, Farmacija, Javno zdravstvo i zdravstvena zaštita