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Pregled bibliografske jedinice broj: 1124798

The mode of antibacterial action of quaternary N- benzylimidazole salts against emerging opportunistic pathogens


Crnčević, Doris; Krce, Lucija; Mastelić, Linda; Maravić, Ana; Soldo, Barbara; Aviani, Ivica; Primožič, Ines; Odžak, Renata; Šprung, Matilda
The mode of antibacterial action of quaternary N- benzylimidazole salts against emerging opportunistic pathogens // Bioorganic chemistry, 112 (2021), 104938, 8 doi:10.1016/j.bioorg.2021.104938 (međunarodna recenzija, članak, znanstveni)


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Naslov
The mode of antibacterial action of quaternary N- benzylimidazole salts against emerging opportunistic pathogens

Autori
Crnčević, Doris ; Krce, Lucija ; Mastelić, Linda ; Maravić, Ana ; Soldo, Barbara ; Aviani, Ivica ; Primožič, Ines ; Odžak, Renata ; Šprung, Matilda

Izvornik
Bioorganic chemistry (0045-2068) 112 (2021); 104938, 8

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
quaternary ammonium compounds, mode of action, emerging pathogens, benzylimidazolium compounds, antimicrobial activity, cytotoxicity

Sažetak
Quaternary ammonium compounds (QACs) are antimicrobial agents displaying a broad spectrum of activity due to their mechanism of action targeting the bacterial membrane. The emergence of bacterial resistance to QACs, especially in times of pandemics, requires the continuous search for new and potent QACs structures. Here we report the synthesis and biological evaluation of QACs based on imidazole derivative, N-benzylimidazole. The antimicrobial activity was tested against a range of pathogenic bacteria and fungi, both ATCC and clinical isolates, showing varying activities ranging in minimal inhibitory concentrations (MICs) from as low as 7 ng/mL. The most promising compound, N-tetradecyl derivative (BnI-14), proved to be very potent against bacterial biofilms, even at sub-MIC doses, suggesting interference with the bacterial growth and/or division process. The BnI-14 treatment induces bacterial membrane disruption, as observed by fluorescence spectroscopy and atomic force microscopy and it also binds to DNA indicating that bacterial membrane might not be the only cellular target of QACs. Most importantly, BnI-14 exhibits low toxicity to healthy human cell lines, suggesting that N- benzylimidazolium-based QACs may be promising new antimicrobial agents.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Ustanove:
Prirodoslovno-matematički fakultet, Zagreb,
Prirodoslovno-matematički fakultet, Split

Citiraj ovu publikaciju

Crnčević, Doris; Krce, Lucija; Mastelić, Linda; Maravić, Ana; Soldo, Barbara; Aviani, Ivica; Primožič, Ines; Odžak, Renata; Šprung, Matilda
The mode of antibacterial action of quaternary N- benzylimidazole salts against emerging opportunistic pathogens // Bioorganic chemistry, 112 (2021), 104938, 8 doi:10.1016/j.bioorg.2021.104938 (međunarodna recenzija, članak, znanstveni)
Crnčević, D., Krce, L., Mastelić, L., Maravić, A., Soldo, B., Aviani, I., Primožič, I., Odžak, R. & Šprung, M. (2021) The mode of antibacterial action of quaternary N- benzylimidazole salts against emerging opportunistic pathogens. Bioorganic chemistry, 112, 104938, 8 doi:10.1016/j.bioorg.2021.104938.
@article{article, year = {2021}, pages = {8}, DOI = {10.1016/j.bioorg.2021.104938}, chapter = {104938}, keywords = {quaternary ammonium compounds, mode of action, emerging pathogens, benzylimidazolium compounds, antimicrobial activity, cytotoxicity}, journal = {Bioorganic chemistry}, doi = {10.1016/j.bioorg.2021.104938}, volume = {112}, issn = {0045-2068}, title = {The mode of antibacterial action of quaternary N- benzylimidazole salts against emerging opportunistic pathogens}, keyword = {quaternary ammonium compounds, mode of action, emerging pathogens, benzylimidazolium compounds, antimicrobial activity, cytotoxicity}, chapternumber = {104938} }
@article{article, year = {2021}, pages = {8}, DOI = {10.1016/j.bioorg.2021.104938}, chapter = {104938}, keywords = {quaternary ammonium compounds, mode of action, emerging pathogens, benzylimidazolium compounds, antimicrobial activity, cytotoxicity}, journal = {Bioorganic chemistry}, doi = {10.1016/j.bioorg.2021.104938}, volume = {112}, issn = {0045-2068}, title = {The mode of antibacterial action of quaternary N- benzylimidazole salts against emerging opportunistic pathogens}, keyword = {quaternary ammonium compounds, mode of action, emerging pathogens, benzylimidazolium compounds, antimicrobial activity, cytotoxicity}, chapternumber = {104938} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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